PSPH (phosphoserine phosphatase)

2012-01-01  

Identity

HGNC
PSPH
LOCATION
7p11.2
LOCUSID
5723
ALIAS
PSP,PSPHD
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5723
MIM: 172480
HGNC: 9577
Ensembl: ENSG00000146733

Variants:

dbSNP: 5723
ClinVar: 5723
TCGA: ENSG00000146733
COSMIC: PSPH

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000146733ENST00000275605P78330
ENSG00000146733ENST00000275605A0A024RDL3
ENSG00000146733ENST00000395471P78330
ENSG00000146733ENST00000395471A0A024RDL3
ENSG00000146733ENST00000419984C9JEJ7
ENSG00000146733ENST00000421312C9JEJ7
ENSG00000146733ENST00000421626C9JBI3
ENSG00000146733ENST00000424596A0A1D5RMN5
ENSG00000146733ENST00000427797F8WD74
ENSG00000146733ENST00000437355P78330
ENSG00000146733ENST00000437355A0A024RDL3

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycine, serine and threonine metabolismKEGGko00260
Glycine, serine and threonine metabolismKEGGhsa00260
Metabolic pathwaysKEGGhsa01100
Serine biosynthesis, glycerate-3P => serineKEGGhsa_M00020
Serine biosynthesis, glycerate-3P => serineKEGGM00020
Biosynthesis of amino acidsKEGGhsa01230
Biosynthesis of amino acidsKEGGko01230
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Amino acid synthesis and interconversion (transamination)REACTOMER-HSA-70614
Serine biosynthesisREACTOMER-HSA-977347

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA450423l-methionineChemicalLiterature, MultilinkAnnotationassociated24651765

References

Pubmed IDYearTitleCitations
336747452021PSPH promotes melanoma growth and metastasis by metabolic deregulation-mediated transcriptional activation of NR4A1.13
336747452021PSPH promotes melanoma growth and metastasis by metabolic deregulation-mediated transcriptional activation of NR4A1.13
306623582019PSPH Mediates the Metastasis and Proliferation of Non-small Cell Lung Cancer through MAPK Signaling Pathways.14
312050212019Crystal structures and snapshots along the reaction pathway of human phosphoserine phosphatase.7
314467472019Phosphoserine Phosphatase Promotes Lung Cancer Progression through the Dephosphorylation of IRS-1 and a Noncanonical L-Serine-Independent Pathway.10
306623582019PSPH Mediates the Metastasis and Proliferation of Non-small Cell Lung Cancer through MAPK Signaling Pathways.14
312050212019Crystal structures and snapshots along the reaction pathway of human phosphoserine phosphatase.7
314467472019Phosphoserine Phosphatase Promotes Lung Cancer Progression through the Dephosphorylation of IRS-1 and a Noncanonical L-Serine-Independent Pathway.10
284768022017Phosphoserine Phosphatase Is a Novel Prognostic Biomarker on Chromosome 7 in Colorectal Cancer.21
284768022017Phosphoserine Phosphatase Is a Novel Prognostic Biomarker on Chromosome 7 in Colorectal Cancer.21
250801662015Phosphoserine phosphatase (PSPH) gene mutation in an intellectual disability family from Pakistan.4
257933152015cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions.152
250801662015Phosphoserine phosphatase (PSPH) gene mutation in an intellectual disability family from Pakistan.4
257933152015cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions.152
251524572014Neu-Laxova syndrome is a heterogeneous metabolic disorder caused by defects in enzymes of the L-serine biosynthesis pathway.44

Citation

Dessen P

PSPH (phosphoserine phosphatase)

Atlas Genet Cytogenet Oncol Haematol. 2012-01-01

Online version: http://atlasgeneticsoncology.org/gene/52528/favicon/css/card-gene.css