PSPH (phosphoserine phosphatase)

2012-01-01  

Identity

HGNC
LOCATION
7p11.2
LOCUSID
ALIAS
PSP,PSPHD
FUSION GENES

Other Information

Locus ID:

NCBI: 5723
MIM: 172480
HGNC: 9577
Ensembl: ENSG00000146733

Variants:

dbSNP: 5723
ClinVar: 5723
TCGA: ENSG00000146733
COSMIC: PSPH

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000146733ENST00000275605P78330
ENSG00000146733ENST00000275605A0A024RDL3
ENSG00000146733ENST00000395471P78330
ENSG00000146733ENST00000395471A0A024RDL3
ENSG00000146733ENST00000419984C9JEJ7
ENSG00000146733ENST00000421312C9JEJ7
ENSG00000146733ENST00000421626C9JBI3
ENSG00000146733ENST00000424596A0A1D5RMN5
ENSG00000146733ENST00000427797F8WD74
ENSG00000146733ENST00000437355P78330
ENSG00000146733ENST00000437355A0A024RDL3

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Glycine, serine and threonine metabolismKEGGko00260
Glycine, serine and threonine metabolismKEGGhsa00260
Metabolic pathwaysKEGGhsa01100
Serine biosynthesis, glycerate-3P => serineKEGGhsa_M00020
Serine biosynthesis, glycerate-3P => serineKEGGM00020
Biosynthesis of amino acidsKEGGhsa01230
Biosynthesis of amino acidsKEGGko01230
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Amino acid synthesis and interconversion (transamination)REACTOMER-HSA-70614
Serine biosynthesisREACTOMER-HSA-977347

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA450423l-methionineChemicalLiterature, MultilinkAnnotationassociated24651765

References

Pubmed IDYearTitleCitations
336747452021PSPH promotes melanoma growth and metastasis by metabolic deregulation-mediated transcriptional activation of NR4A1.13
336747452021PSPH promotes melanoma growth and metastasis by metabolic deregulation-mediated transcriptional activation of NR4A1.13
306623582019PSPH Mediates the Metastasis and Proliferation of Non-small Cell Lung Cancer through MAPK Signaling Pathways.14
312050212019Crystal structures and snapshots along the reaction pathway of human phosphoserine phosphatase.7
314467472019Phosphoserine Phosphatase Promotes Lung Cancer Progression through the Dephosphorylation of IRS-1 and a Noncanonical L-Serine-Independent Pathway.10
306623582019PSPH Mediates the Metastasis and Proliferation of Non-small Cell Lung Cancer through MAPK Signaling Pathways.14
312050212019Crystal structures and snapshots along the reaction pathway of human phosphoserine phosphatase.7
314467472019Phosphoserine Phosphatase Promotes Lung Cancer Progression through the Dephosphorylation of IRS-1 and a Noncanonical L-Serine-Independent Pathway.10
284768022017Phosphoserine Phosphatase Is a Novel Prognostic Biomarker on Chromosome 7 in Colorectal Cancer.21
284768022017Phosphoserine Phosphatase Is a Novel Prognostic Biomarker on Chromosome 7 in Colorectal Cancer.21
250801662015Phosphoserine phosphatase (PSPH) gene mutation in an intellectual disability family from Pakistan.4
257933152015cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions.152
250801662015Phosphoserine phosphatase (PSPH) gene mutation in an intellectual disability family from Pakistan.4
257933152015cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions.152
251524572014Neu-Laxova syndrome is a heterogeneous metabolic disorder caused by defects in enzymes of the L-serine biosynthesis pathway.44

Citation

Dessen P

PSPH (phosphoserine phosphatase)

Atlas Genet Cytogenet Oncol Haematol. 2012-01-01

Online version: http://atlasgeneticsoncology.org/gene/52528/js/lib/favicon/apple-touch-icon.png