CMPK1 (cytidine/uridine monophosphate kinase 1)

2012-01-01  

Identity

HGNC
CMPK1
LOCATION
1p33
LOCUSID
51727
ALIAS
CK,CMK,CMPK,UMK,UMP-CMPK,UMPK
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51727
MIM: 191710
HGNC: 18170
Ensembl: ENSG00000162368

Variants:

dbSNP: 51727
ClinVar: 51727
TCGA: ENSG00000162368
COSMIC: CMPK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162368ENST00000371871Q5T0D2
ENSG00000162368ENST00000371873P30085
ENSG00000162368ENST00000450808A0A494BXC7
ENSG00000162368ENST00000471289E9PJD2

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Pyrimidine metabolismKEGGko00240
Pyrimidine metabolismKEGGhsa00240
Metabolic pathwaysKEGGhsa01100
Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTPKEGGhsa_M00052
Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTPKEGGM00052
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Synthesis and interconversion of nucleotide di- and triphosphatesREACTOMER-HSA-499943

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443622Carcinoma, Non-Small-Cell LungDiseaseClinicalAnnotationassociatedPD21642870
PA445062NeoplasmsDiseaseClinicalAnnotationassociatedPKPD21642870, 22838949, 22838950, 24361227
PA445218Pancreatic NeoplasmsDiseaseClinicalAnnotationassociatedPD22838950
PA449014cisplatinChemicalClinicalAnnotationassociatedPD21642870
PA449748gemcitabineChemicalClinicalAnnotationassociatedPKPD21642870, 22838949, 22838950, 24361227
PA450163lamivudineChemicalPathwayassociated

References

Pubmed IDYearTitleCitations
372583942023Twenty-Four Percent of Wildland Firefighters Reach Critical Levels of Serum Creatine Kinase During 80-Hour Critical Training.0
372583942023Twenty-Four Percent of Wildland Firefighters Reach Critical Levels of Serum Creatine Kinase During 80-Hour Critical Training.0
312018692019MiR-3613-3p impairs IFN-induced immune response by targeting CMPK1 in chronic hepatitis B.3
312018692019MiR-3613-3p impairs IFN-induced immune response by targeting CMPK1 in chronic hepatitis B.3
284141002017Cytidine monophosphate kinase is inhibited by the TGF-β signalling pathway through the upregulation of miR-130b-3p in human epithelial ovarian cancer.21
284141002017Cytidine monophosphate kinase is inhibited by the TGF-β signalling pathway through the upregulation of miR-130b-3p in human epithelial ovarian cancer.21
275586612016Prognostic significance of nuclear expression of UMP-CMP kinase in triple negative breast cancer patients.9
275586612016Prognostic significance of nuclear expression of UMP-CMP kinase in triple negative breast cancer patients.9
256590342015The contribution of CMP kinase to the efficiency of DNA repair.6
256590342015The contribution of CMP kinase to the efficiency of DNA repair.6
249631612014CMPK1 and RBP3 are associated with corneal curvature in Asian populations.13
249631612014CMPK1 and RBP3 are associated with corneal curvature in Asian populations.13
228389502012Effect of genetic polymorphisms on therapeutic response and clinical outcomes in pancreatic cancer patients treated with gemcitabine.7
228389502012Effect of genetic polymorphisms on therapeutic response and clinical outcomes in pancreatic cancer patients treated with gemcitabine.7
215592902011UMP/CMPK is not the critical enzyme in the metabolism of pyrimidine ribonucleotide and activation of deoxycytidine analogs in human RKO cells.3

Citation

Dessen P

CMPK1 (cytidine/uridine monophosphate kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2012-01-01

Online version: http://atlasgeneticsoncology.org/gene/52552/gene-explorer/favicon/favicon-16x16.png