ARL2BP (ADP ribosylation factor like GTPase 2 binding protein)

2012-01-01  

Identity

HGNC
ARL2BP
LOCATION
16q13
LOCUSID
23568
ALIAS
BART,BART1,RP66
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23568
MIM: 615407
HGNC: 17146
Ensembl: ENSG00000102931

Variants:

dbSNP: 23568
ClinVar: 23568
TCGA: ENSG00000102931
COSMIC: ARL2BP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102931ENST00000219204Q9Y2Y0
ENSG00000102931ENST00000219204A0A024R6U9
ENSG00000102931ENST00000562023H3BU49
ENSG00000102931ENST00000563234H3BM52

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Integration of energy metabolismREACTOMER-HSA-163685
Regulation of insulin secretionREACTOMER-HSA-422356

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
334385812021ARL3 activation requires the co-GEF BART and effector-mediated turnover.10
346815962021Epstein-Barr Virus miR-BART1-3p Regulates the miR-17-92 Cluster by Targeting E2F3.8
334385812021ARL3 activation requires the co-GEF BART and effector-mediated turnover.10
346815962021Epstein-Barr Virus miR-BART1-3p Regulates the miR-17-92 Cluster by Targeting E2F3.8
314255462019Mutations in ARL2BP, a protein required for ciliary microtubule structure, cause syndromic male infertility in humans and mice.13
314255462019Mutations in ARL2BP, a protein required for ciliary microtubule structure, cause syndromic male infertility in humans and mice.13
302102312018Novel homozygous splicing mutations in ARL2BP cause autosomal recessive retinitis pigmentosa.7
302102312018Novel homozygous splicing mutations in ARL2BP cause autosomal recessive retinitis pigmentosa.7
277907022017ARL2BP mutations account for 0.1% of autosomal recessive rod-cone dystrophies with the report of a novel splice variant.7
277907022017ARL2BP mutations account for 0.1% of autosomal recessive rod-cone dystrophies with the report of a novel splice variant.7
261356192015Epstein-Barr virus-encoded microRNA BART1 induces tumour metastasis by regulating PTEN-dependent pathways in nasopharyngeal carcinoma.126
261356192015Epstein-Barr virus-encoded microRNA BART1 induces tumour metastasis by regulating PTEN-dependent pathways in nasopharyngeal carcinoma.126
248991732014MicroRNA miR-BART20-5p stabilizes Epstein-Barr virus latency by directly targeting BZLF1 and BRLF1.54
248991732014MicroRNA miR-BART20-5p stabilizes Epstein-Barr virus latency by directly targeting BZLF1 and BRLF1.54
236851472013EBV-miR-BART1 is involved in regulating metabolism-associated genes in nasopharyngeal carcinoma.38

Citation

Dessen P

ARL2BP (ADP ribosylation factor like GTPase 2 binding protein)

Atlas Genet Cytogenet Oncol Haematol. 2012-01-01

Online version: http://atlasgeneticsoncology.org/gene/52555/js/lib/js/lib/bootstrap.min.js