APLP2 (amyloid beta precursor like protein 2)

2012-01-01  

Identity

HGNC
APLP2
LOCATION
11q24.3
LOCUSID
334
ALIAS
APLP-2,APPH,APPL2,CDEBP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 334
MIM: 104776
HGNC: 598
Ensembl: ENSG00000084234

Variants:

dbSNP: 334
ClinVar: 334
TCGA: ENSG00000084234
COSMIC: APLP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000084234ENST00000263574Q06481
ENSG00000084234ENST00000278756Q06481
ENSG00000084234ENST00000338167Q06481
ENSG00000084234ENST00000338167A0A140VJE9
ENSG00000084234ENST00000345598Q06481
ENSG00000084234ENST00000528499Q06481
ENSG00000084234ENST00000530132Q9UED0
ENSG00000084234ENST00000533195E9PSC7
ENSG00000084234ENST00000533616E9PPD0
ENSG00000084234ENST00000533713E9PQS3
ENSG00000084234ENST00000534582E9PK76
ENSG00000084234ENST00000650012Q06481

Expression (GTEx)

0
100
200
300
400
500
600
700
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
375154942024Comprehensive intratumoral heterogeneity landscaping of liver hepatocellular carcinoma and discerning of APLP2 in cancer progression.5
381480842024Implication of Amyloid Precursor-like Protein 2 Expression in Cutaneous Squamous Cell Carcinoma Pathogenesis.0
375154942024Comprehensive intratumoral heterogeneity landscaping of liver hepatocellular carcinoma and discerning of APLP2 in cancer progression.5
381480842024Implication of Amyloid Precursor-like Protein 2 Expression in Cutaneous Squamous Cell Carcinoma Pathogenesis.0
366913152023APLP2 is predominantly cleaved by β-secretase and γ-secretase in the human brain.0
378444662023Mycobacterium tuberculosis suppresses APLP2 expression to enhance its survival in macrophage.1
366913152023APLP2 is predominantly cleaved by β-secretase and γ-secretase in the human brain.0
378444662023Mycobacterium tuberculosis suppresses APLP2 expression to enhance its survival in macrophage.1
327160392020APLP2 gene polymorphisms are associated with high TC and LDL-C levels in Chinese population in Xinjiang, China.1
327160392020APLP2 gene polymorphisms are associated with high TC and LDL-C levels in Chinese population in Xinjiang, China.1
308104352019Beta 2-microglobulin regulates amyloid precursor-like protein 2 expression and the migration of pancreatic cancer cells.6
308104352019Beta 2-microglobulin regulates amyloid precursor-like protein 2 expression and the migration of pancreatic cancer cells.6
296637382018Expression of amyloid precursor-like protein 2 (APLP2) in glioblastoma is associated with patient prognosis.7
296637382018Expression of amyloid precursor-like protein 2 (APLP2) in glioblastoma is associated with patient prognosis.7
277961942017APLP2, RRM2, and PRC1: New Putative Markers for the Differential Diagnosis of Thyroid Follicular Lesions.4

Citation

Dessen P

APLP2 (amyloid beta precursor like protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2012-01-01

Online version: http://atlasgeneticsoncology.org/gene/52577/gene-explorer/img/logo-atlas-4.svg