EBI3 (Epstein-Barr virus induced 3)

2012-03-01  

Identity

HGNC
LOCATION
19p13.3
LOCUSID
ALIAS
IL-27B,IL27B,IL35B
FUSION GENES

Other Information

Locus ID:

NCBI: 10148
MIM: 605816
HGNC: 3129
Ensembl: ENSG00000105246

Variants:

dbSNP: 10148
ClinVar: 10148
TCGA: ENSG00000105246
COSMIC: EBI3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105246ENST00000221847Q14213

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
500

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-6 family signalingREACTOMER-HSA-6783589
IL-6-type cytokine receptor ligand interactionsREACTOMER-HSA-6788467

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
121216602002IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells.396
247433052014Interleukin-35 induces regulatory B cells that suppress autoimmune disease.163
224389682012IL-35 is a novel responsive anti-inflammatory cytokine--a new system of categorizing anti-inflammatory cytokines.77
223436302012Influenza A virus induces interleukin-27 through cyclooxygenase-2 and protein kinase A signaling.26
231541822013IL-35 over-expression increases apoptosis sensitivity and suppresses cell growth in human cancer cells.25
239044412013Modulation of inflammation by interleukin-27.25
241210412014Circulating IL-35 in pancreatic ductal adenocarcinoma patients.23
195565162009Epstein-barr virus-induced gene-3 is expressed in human atheroma plaques.21
212850062011Detectable expression of IL-35 in CD4+ T cells from peripheral blood of chronic hepatitis B patients.21
236194692013Human placental trophoblasts express the immunosuppressive cytokine IL-35.18

Citation

Dessen P

EBI3 (Epstein-Barr virus induced 3)

Atlas Genet Cytogenet Oncol Haematol. 2012-03-01

Online version: http://atlasgeneticsoncology.org/gene/52627/ebi3