FHOD1 (formin homology 2 domain containing 1)

2012-03-01  

Identity

HGNC
FHOD1
LOCATION
16q22.1
LOCUSID
29109
ALIAS
FHOS
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 29109
MIM: 606881
HGNC: 17905
Ensembl: ENSG00000135723

Variants:

dbSNP: 29109
ClinVar: 29109
TCGA: ENSG00000135723
COSMIC: FHOD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135723ENST00000258201Q9Y613
ENSG00000135723ENST00000561922H3BVE7
ENSG00000135723ENST00000567509J3KTH7
ENSG00000135723ENST00000567561J3KT53
ENSG00000135723ENST00000568595J3QR24

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
372119492023FHOD1 is upregulated in glioma cells and attenuates ferroptosis of glioma cells by targeting HSPB1 signaling.3
372119492023FHOD1 is upregulated in glioma cells and attenuates ferroptosis of glioma cells by targeting HSPB1 signaling.3
334720392021Structures of FHOD1-Nesprin1/2 complexes reveal alternate binding modes for the FH3 domain of formins.6
334720392021Structures of FHOD1-Nesprin1/2 complexes reveal alternate binding modes for the FH3 domain of formins.6
327274042020Multiple formin proteins participate in glioblastoma migration.13
327274042020Multiple formin proteins participate in glioblastoma migration.13
316574392019Active FHOD1 promotes the formation of functional actin stress fibers.3
316574392019Active FHOD1 promotes the formation of functional actin stress fibers.3
279197462017FHOD1 formin is upregulated in melanomas and modifies proliferation and tumor growth.13
284555032017Lamins and nesprin-1 mediate inside-out mechanical coupling in muscle cell precursors through FHOD1.26
279197462017FHOD1 formin is upregulated in melanomas and modifies proliferation and tumor growth.13
284555032017Lamins and nesprin-1 mediate inside-out mechanical coupling in muscle cell precursors through FHOD1.26
266210332016The formins FHOD1 and INF2 regulate inter- and intra-structural contractility of podosomes.25
266210332016The formins FHOD1 and INF2 regulate inter- and intra-structural contractility of podosomes.25
255554642015Distribution of formins in cardiac muscle: FHOD1 is a component of intercalated discs and costameres.12

Citation

Dessen P

FHOD1 (formin homology 2 domain containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2012-03-01

Online version: http://atlasgeneticsoncology.org/gene/52628/case-report-explorer/js/lib/jquery-3.5.1.min.js