GPRC6A (G protein-coupled receptor class C group 6 member A)

2012-03-01  

Identity

HGNC
LOCATION
6q22.1
LOCUSID
ALIAS
GPCR,bA86F4.3

Other Information

Locus ID:

NCBI: 222545
MIM: 613572
HGNC: 18510
Ensembl: ENSG00000173612

Variants:

dbSNP: 222545
ClinVar: 222545
TCGA: ENSG00000173612
COSMIC: GPRC6A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173612ENST00000310357Q5T6X5
ENSG00000173612ENST00000368549Q5T6X5
ENSG00000173612ENST00000530250Q5T6X5

Expression (GTEx)

0
1

Pathways

PathwaySourceExternal ID
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class C/3 (Metabotropic glutamate/pheromone receptors)REACTOMER-HSA-420499
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

References

Pubmed IDYearTitleCitations
354822142022RS 2247911 polymorphism of GPRC6A gene and serum undercarboxylated-osteocalcin are associated with testis function.1
354822142022RS 2247911 polymorphism of GPRC6A gene and serum undercarboxylated-osteocalcin are associated with testis function.1
334745662021Explaining Divergent Observations Regarding Osteocalcin/GPRC6A Endocrine Signaling.8
334745662021Explaining Divergent Observations Regarding Osteocalcin/GPRC6A Endocrine Signaling.8
326364822020Humanized GPRC6A(KGKY) is a gain-of-function polymorphism in mice.10
328276812020rs2274911 polymorphism in GPRC6A associated with serum E2 and PSA in a Southern Chinese male population.4
328595442020Analysis of GPRC6A variants in different pancreatitis etiologies.1
326364822020Humanized GPRC6A(KGKY) is a gain-of-function polymorphism in mice.10
328276812020rs2274911 polymorphism in GPRC6A associated with serum E2 and PSA in a Southern Chinese male population.4
328595442020Analysis of GPRC6A variants in different pancreatitis etiologies.1
307079082019Membrane androgen receptors (OXER1, GPRC6A AND ZIP9) in prostate and breast cancer: A comparative study of their expression.21
308944042019Human GPRC6A Mediates Testosterone-Induced Mitogen-Activated Protein Kinases and mTORC1 Signaling in Prostate Cancer Cells.16
318576542019SHBG141-161 Domain-Peptide Stimulates GPRC6A-Mediated Response in Leydig and β-Langerhans cell lines.3
307079082019Membrane androgen receptors (OXER1, GPRC6A AND ZIP9) in prostate and breast cancer: A comparative study of their expression.21
308944042019Human GPRC6A Mediates Testosterone-Induced Mitogen-Activated Protein Kinases and mTORC1 Signaling in Prostate Cancer Cells.16

Citation

Dessen P

GPRC6A (G protein-coupled receptor class C group 6 member A)

Atlas Genet Cytogenet Oncol Haematol. 2012-03-01

Online version: http://atlasgeneticsoncology.org/gene/52630/deep-insight-explorer/img/css/card-gene.css