SUB1 (SUB1 regulator of transcription)

2012-03-01  

Identity

HGNC
SUB1
LOCATION
5p13.3
LOCUSID
10923
ALIAS
P15,PC4,p14
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10923
MIM: 600503
HGNC: 19985
Ensembl: ENSG00000113387

Variants:

dbSNP: 10923
ClinVar: 10923
TCGA: ENSG00000113387
COSMIC: SUB1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000113387ENST00000265073P53999
ENSG00000113387ENST00000265073Q6IBA2
ENSG00000113387ENST00000502897P53999
ENSG00000113387ENST00000502897Q6IBA2
ENSG00000113387ENST00000506237P53999
ENSG00000113387ENST00000506237Q6IBA2
ENSG00000113387ENST00000510442D6RC37
ENSG00000113387ENST00000511615D6R970
ENSG00000113387ENST00000512913P53999
ENSG00000113387ENST00000512913Q6IBA2
ENSG00000113387ENST00000515355P53999
ENSG00000113387ENST00000515355Q6IBA2

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203053792010Sub1/PC4 a chromatin associated protein with multiple functions in transcription.32
169827012006Transcriptional coactivator PC4, a chromatin-associated protein, induces chromatin condensation.29
195252312009Interaction between the transactivation domain of p53 and PC4 exemplifies acidic activation domains as single-stranded DNA mimics.24
263502172015Cooperation between SMYD3 and PC4 drives a distinct transcriptional program in cancer cells.23
272704422016MicroRNA-101 regulated transcriptional modulator SUB1 plays a role in prostate cancer.22
177854492007Activation of p53 function by human transcriptional coactivator PC4: role of protein-protein interaction, DNA bending, and posttranslational modifications.21
149662842004General transcriptional coactivator PC4 activates p53 function.20
190474592008Recruitment of RNA polymerase II cofactor PC4 to DNA damage sites.20
164158822006A global transcription cofactor bound to juxtaposed strands of unwound DNA.19
200801052010Human positive coactivator 4 controls heterochromatinization and silencing of neural gene expression by interacting with REST/NRSF and CoREST.19

Citation

Dessen P

SUB1 (SUB1 regulator of transcription)

Atlas Genet Cytogenet Oncol Haematol. 2012-03-01

Online version: http://atlasgeneticsoncology.org/gene/52643/sub1