SCARB2 (scavenger receptor class B member 2)

2012-04-01 Affiliation

Identity

HGNC

SCARB2

LOCATION

4q21.1

LOCUSID

950

ALIAS

AMRF,CD36L2,EPM4,HLGP85,LGP85,LIMP-2,LIMPII,SR-BII

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 950
MIM: 602257
HGNC: 1665
Ensembl: ENSG00000138760

Variants:

dbSNP: 950
ClinVar: 950
TCGA: ENSG00000138760
COSMIC: SCARB2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000138760	ENST00000264896	Q14108
ENSG00000138760	ENST00000264896	A0A024RDG6
ENSG00000138760	ENST00000452464	Q14108
ENSG00000138760	ENST00000509994	D6RDG0
ENSG00000138760	ENST00000638295	A0A1W2PRF6
ENSG00000138760	ENST00000638603	A0A1W2PPU6
ENSG00000138760	ENST00000638663	A0A1W2PPX5
ENSG00000138760	ENST00000639145	A0A1W2PS43
ENSG00000138760	ENST00000639300	A0A1W2PSE4
ENSG00000138760	ENST00000639715	A0A1W2PNX7
ENSG00000138760	ENST00000639738	A0A1W2PQL5
ENSG00000138760	ENST00000640341	A0A1W2PS70
ENSG00000138760	ENST00000640634	A0A1W2PRS1
ENSG00000138760	ENST00000640640	A0A1W2PQR6
ENSG00000138760	ENST00000640880	A0A1W2PPX6
ENSG00000138760	ENST00000640957	A0A1W2PQB7

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Lysosome	KEGG	ko04142
Lysosome	KEGG	hsa04142
Vesicle-mediated transport	REACTOME	R-HSA-5653656
Membrane Trafficking	REACTOME	R-HSA-199991
Clathrin-mediated endocytosis	REACTOME	R-HSA-8856828
Cargo recognition for clathrin-mediated endocytosis	REACTOME	R-HSA-8856825

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
19543282	2009	Scavenger receptor B2 is a cellular receptor for enterovirus 71.	200
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
17110915	2006	Intraretinal lipid transport is dependent on high density lipoprotein-like particles and class B scavenger receptors.	80
24973356	2014	Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies.	72
18308289	2008	Array-based gene discovery with three unrelated subjects shows SCARB2/LIMP-2 deficiency causes myoclonus epilepsy and glomerulosclerosis.	70
17215280	2007	Scavenger receptor BI and BII expression levels modulate hepatitis C virus infectivity.	65
22219187	2012	Molecular determinants of enterovirus 71 viral entry: cleft around GLN-172 on VP1 protein interacts with variable region on scavenge receptor B 2.	54
22438546	2012	Human SCARB2-dependent infection by coxsackievirus A7, A14, and A16 and enterovirus 71.	54
23959904	2013	Transgenic mouse model for the study of enterovirus 71 neuropathogenesis.	51
23302872	2013	Functional comparison of SCARB2 and PSGL1 as receptors for enterovirus 71.	48

Citation

Dessen P

SCARB2 (scavenger receptor class B member 2)

Atlas Genet Cytogenet Oncol Haematol. 2012-04-01

Online version: http://atlasgeneticsoncology.org/gene/52675/scarb2