ECD (ecdysoneless cell cycle regulator)

2012-05-01  

Identity

HGNC
LOCATION
10q22.2
LOCUSID
ALIAS
GCR2,HSGT1,SGT1
FUSION GENES

Other Information

Locus ID:

NCBI: 11319
MIM: 616464
HGNC: 17029
Ensembl: ENSG00000122882

Variants:

dbSNP: 11319
ClinVar: 11319
TCGA: ENSG00000122882
COSMIC: ECD

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000122882ENST00000372979O95905
ENSG00000122882ENST00000413026C9JGV1
ENSG00000122882ENST00000430082O95905
ENSG00000122882ENST00000453402C9J316
ENSG00000122882ENST00000454759O95905
ENSG00000122882ENST00000484976F2Z2R1
ENSG00000122882ENST00000494307S4R458

Expression (GTEx)

0
5
10
15
20
25
30
35

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
229771922012Overexpression of ecdysoneless in pancreatic cancer and its role in oncogenesis by regulating glycolysis.12
222709302012Overexpression of a novel cell cycle regulator ecdysoneless in breast cancer: a marker of poor prognosis in HER2/neu-overexpressing breast cancer patients.10
267112702015A Novel Interaction of Ecdysoneless (ECD) Protein with R2TP Complex Component RUVBL1 Is Required for the Functional Role of ECD in Cell Cycle Progression.9
238803452013TXNIP interacts with hEcd to increase p53 stability and activity.7
297066182018ECD promotes gastric cancer metastasis by blocking E3 ligase ZFP91-mediated hnRNP F ubiquitination and degradation.7
199191812010Biochemical characterization of human Ecdysoneless reveals a role in transcriptional regulation.6
256165802015The cell cycle regulator ecdysoneless cooperates with H-Ras to promote oncogenic transformation of human mammary epithelial cells.5

Citation

Dessen P

ECD (ecdysoneless cell cycle regulator)

Atlas Genet Cytogenet Oncol Haematol. 2012-05-01

Online version: http://atlasgeneticsoncology.org/gene/52712/ecd