APOBEC2 (apolipoprotein B mRNA editing enzyme catalytic subunit 2)

2012-06-01  

Identity

HGNC
APOBEC2
LOCATION
6p21.1
LOCUSID
10930
ALIAS
ARCD1,ARP1

Other Information

Locus ID:

NCBI: 10930
MIM: 604797
HGNC: 605
Ensembl: ENSG00000124701

Variants:

dbSNP: 10930
ClinVar: 10930
TCGA: ENSG00000124701
COSMIC: APOBEC2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124701ENST00000244669Q9Y235

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
mRNA EditingREACTOMER-HSA-75072
mRNA Editing: C to U ConversionREACTOMER-HSA-72200
Formation of the EditosomeREACTOMER-HSA-75094

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381667442024Expression and prognostic value of APOBEC2 in gastric adenocarcinoma and its association with tumor-infiltrating immune cells.0
381667442024Expression and prognostic value of APOBEC2 in gastric adenocarcinoma and its association with tumor-infiltrating immune cells.0
214691432012Excessive activity of apolipoprotein B mRNA editing enzyme catalytic polypeptide 2 (APOBEC2) contributes to liver and lung tumorigenesis.28
214691432012Excessive activity of apolipoprotein B mRNA editing enzyme catalytic polypeptide 2 (APOBEC2) contributes to liver and lung tumorigenesis.28
201388412010Microarray analysis of tonsils in immunoglobulin A nephropathy patients.7
201388412010Microarray analysis of tonsils in immunoglobulin A nephropathy patients.7
199111242009APOBEC deaminases-mutases with defensive roles for immunity.16
199111242009APOBEC deaminases-mutases with defensive roles for immunity.16
189748422008Gender differences in genetic risk profiles for cardiovascular disease.46
189748422008Gender differences in genetic risk profiles for cardiovascular disease.46
171870542007The APOBEC-2 crystal structure and functional implications for the deaminase AID.122
171870542007The APOBEC-2 crystal structure and functional implications for the deaminase AID.122

Citation

Dessen P

APOBEC2 (apolipoprotein B mRNA editing enzyme catalytic subunit 2)

Atlas Genet Cytogenet Oncol Haematol. 2012-06-01

Online version: http://atlasgeneticsoncology.org/gene/52755/deep-insight-explorer/css/cancer-prone-explorer/js/web-card-gene.js