UGT2B4 (UDP glucuronosyltransferase family 2 member B4)

2012-08-01  

Identity

HGNC
LOCATION
4q13.3
LOCUSID
ALIAS
HLUG25,UDPGT2B4,UDPGTH1,UDPGTh-1,UGT2B11
FUSION GENES

Other Information

Locus ID:

NCBI: 7363
MIM: 600067
HGNC: 12553
Ensembl: ENSG00000156096

Variants:

dbSNP: 7363
ClinVar: 7363
TCGA: ENSG00000156096
COSMIC: UGT2B4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156096ENST00000305107P06133
ENSG00000156096ENST00000510114D6RGY0
ENSG00000156096ENST00000512583P06133
ENSG00000156096ENST00000639621A0A1W2PQJ2

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Pentose and glucuronate interconversionsKEGGko00040
Ascorbate and aldarate metabolismKEGGko00053
Steroid hormone biosynthesisKEGGko00140
Retinol metabolismKEGGko00830
Porphyrin and chlorophyll metabolismKEGGko00860
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Drug metabolism - cytochrome P450KEGGko00982
Drug metabolism - other enzymesKEGGko00983
Pentose and glucuronate interconversionsKEGGhsa00040
Ascorbate and aldarate metabolismKEGGhsa00053
Steroid hormone biosynthesisKEGGhsa00140
Retinol metabolismKEGGhsa00830
Porphyrin and chlorophyll metabolismKEGGhsa00860
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
Drug metabolism - cytochrome P450KEGGhsa00982
Drug metabolism - other enzymesKEGGhsa00983
Metabolic pathwaysKEGGhsa01100
Bile secretionKEGGko04976
Bile secretionKEGGhsa04976
Glucuronate pathway (uronate pathway)KEGGM00014
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
Glucuronate pathway (uronate pathway)KEGGhsa_M00014
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
GlucuronidationREACTOMER-HSA-156588

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA449957ibuprofenChemicalPathwayassociated25502615

References

Pubmed IDYearTitleCitations
368232442023Distilling functional variations for human UGT2B4 upstream region based on selection signals and implications for phenotypes of Neanderthal and Denisovan.0
368232442023Distilling functional variations for human UGT2B4 upstream region based on selection signals and implications for phenotypes of Neanderthal and Denisovan.0
321709862021Absence of significant association between UGT2B4 genetic variants and the susceptibility to anti-tuberculosis drug-induced liver injury in a Western Chinese population.1
321709862021Absence of significant association between UGT2B4 genetic variants and the susceptibility to anti-tuberculosis drug-induced liver injury in a Western Chinese population.1
291382872018Clopidogrel Carboxylic Acid Glucuronidation is Mediated Mainly by UGT2B7, UGT2B4, and UGT2B17: Implications for Pharmacogenetics and Drug-Drug Interactions( ).9
291382872018Clopidogrel Carboxylic Acid Glucuronidation is Mediated Mainly by UGT2B7, UGT2B4, and UGT2B17: Implications for Pharmacogenetics and Drug-Drug Interactions( ).9
272822832016UGT2B4 previously implicated in the risk of breast cancer is associated with menarche timing in Ukrainian females.4
272822832016UGT2B4 previously implicated in the risk of breast cancer is associated with menarche timing in Ukrainian females.4
259487112015Upregulation of UGT2B4 Expression by 3'-Phosphoadenosine-5'-Phosphosulfate Synthase Knockdown: Implications for Coordinated Control of Bile Acid Conjugation.2
259487112015Upregulation of UGT2B4 Expression by 3'-Phosphoadenosine-5'-Phosphosulfate Synthase Knockdown: Implications for Coordinated Control of Bile Acid Conjugation.2
220922982012Methadone inhibits CYP2D6 and UGT2B7/2B4 in vivo: a study using codeine in methadone- and buprenorphine-maintained subjects.7
223670212012High enzyme activity UGT1A1 or low activity UGT1A8 and UGT2B4 genotypes increase esophageal cancer risk.14
220922982012Methadone inhibits CYP2D6 and UGT2B7/2B4 in vivo: a study using codeine in methadone- and buprenorphine-maintained subjects.7
223670212012High enzyme activity UGT1A1 or low activity UGT1A8 and UGT2B4 genotypes increase esophageal cancer risk.14
216605082011A signature of balancing selection in the region upstream to the human UGT2B4 gene and implications for breast cancer risk.20

Citation

Dessen P

UGT2B4 (UDP glucuronosyltransferase family 2 member B4)

Atlas Genet Cytogenet Oncol Haematol. 2012-08-01

Online version: http://atlasgeneticsoncology.org/gene/52838/js/lib/css/template-nav.css