CNDP2 (carnosine dipeptidase 2)

2012-08-01  

Identity

HGNC
LOCATION
18q22.3
LOCUSID
ALIAS
CN2,CPGL,HEL-S-13,HsT2298,PEPA
FUSION GENES

Other Information

Locus ID:

NCBI: 55748
MIM: 169800
HGNC: 24437
Ensembl: ENSG00000133313

Variants:

dbSNP: 55748
ClinVar: 55748
TCGA: ENSG00000133313
COSMIC: CNDP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133313ENST00000324262Q96KP4
ENSG00000133313ENST00000324301Q96KP4
ENSG00000133313ENST00000577355A0A087WVS2
ENSG00000133313ENST00000577600J3QQN6
ENSG00000133313ENST00000579583J3QRA8
ENSG00000133313ENST00000579624J3KRJ8
ENSG00000133313ENST00000579847Q96KP4
ENSG00000133313ENST00000580672J3QRH4
ENSG00000133313ENST00000581272J3QRD0
ENSG00000133313ENST00000581513J3QLU1
ENSG00000133313ENST00000581912J3KSS4
ENSG00000133313ENST00000582260J3QRP4
ENSG00000133313ENST00000582589J3QKQ0
ENSG00000133313ENST00000582666J3KRD5
ENSG00000133313ENST00000583203J3QL02
ENSG00000133313ENST00000583216J3KSV5
ENSG00000133313ENST00000583785J3QKT2
ENSG00000133313ENST00000584613J3QR27
ENSG00000133313ENST00000584768A0A087WYZ1

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Arginine and proline metabolismKEGGko00330
Histidine metabolismKEGGko00340
beta-Alanine metabolismKEGGko00410
Arginine and proline metabolismKEGGhsa00330
Histidine metabolismKEGGhsa00340
beta-Alanine metabolismKEGGhsa00410
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Sulfur amino acid metabolismREACTOMER-HSA-1614635
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
Glutathione conjugationREACTOMER-HSA-156590
Glutathione synthesis and recyclingREACTOMER-HSA-174403

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
193734892009The influence of carnosinase gene polymorphisms on diabetic nephropathy risk in African-Americans.25
187536732008Exclusion of polymorphisms in carnosinase genes (CNDP1 and CNDP2) as a cause of diabetic nephropathy in type 1 diabetes: results of large case-control and follow-up studies.21
187536732008Exclusion of polymorphisms in carnosinase genes (CNDP1 and CNDP2) as a cause of diabetic nephropathy in type 1 diabetes: results of large case-control and follow-up studies.21
215739052011Common variants in CNDP1 and CNDP2, and risk of nephropathy in type 2 diabetes.21
224102442012Proteomic profiling of the substantia nigra demonstrates CNDP2 overexpression in Parkinson's disease.16
201991072010Molecular mechanism of flop selectivity and subsite recognition for an AMPA receptor allosteric modulator: structures of GluA2 and GluA3 in complexes with PEPA.14
259643432015N-lactoyl-amino acids are ubiquitous metabolites that originate from CNDP2-mediated reverse proteolysis of lactate and amino acids.12
221283002012Loss of 18q22.3 involving the carboxypeptidase of glutamate-like gene is associated with poor prognosis in resected pancreatic cancer.10
243955682014Underexpressed CNDP2 participates in gastric cancer growth inhibition through activating the MAPK signaling pathway.7
248853952014Up-regulation of CNDP2 facilitates the proliferation of colon cancer.4

Citation

Dessen P

CNDP2 (carnosine dipeptidase 2)

Atlas Genet Cytogenet Oncol Haematol. 2012-08-01

Online version: http://atlasgeneticsoncology.org/gene/52839/cndp2