DPP6 (dipeptidyl peptidase like 6)

2012-09-01  

Identity

HGNC
LOCATION
7q36.2
LOCUSID
ALIAS
DPL1,DPPX,MRD33,VF2
FUSION GENES

Other Information

Locus ID:

NCBI: 1804
MIM: 126141
HGNC: 3010
Ensembl: ENSG00000130226

Variants:

dbSNP: 1804
ClinVar: 1804
TCGA: ENSG00000130226
COSMIC: DPP6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130226ENST00000332007P42658
ENSG00000130226ENST00000377770P42658
ENSG00000130226ENST00000404039E9PF59
ENSG00000130226ENST00000406326Q8IYG9
ENSG00000130226ENST00000427557E9PDL2
ENSG00000130226ENST00000619756A0A087WTG7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443309AlcoholismDiseaseClinicalAnnotationassociatedPD32451486
PA448073ethanolChemicalClinicalAnnotationassociatedPD32451486
PA449841haloperidolChemicalMultilinkAnnotationassociated27023437

References

Pubmed IDYearTitleCitations
185198262008Molecular genetics of successful smoking cessation: convergent genome-wide association study results.130
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
180842912008Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis.82
180842912008Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis.82
180570692008A genome-wide association study of sporadic ALS in a homogenous Irish population.76
180570692008A genome-wide association study of sporadic ALS in a homogenous Irish population.76
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
232256032013Encephalitis and antibodies to dipeptidyl-peptidase-like protein-6, a subunit of Kv4.2 potassium channels.59
206866082010Genome-wide association study of pancreatic cancer in Japanese population.53
158907032005Expression and function of dipeptidyl-aminopeptidase-like protein 6 as a putative beta-subunit of human cardiac transient outward current encoded by Kv4.3.48

Citation

Dessen P

DPP6 (dipeptidyl peptidase like 6)

Atlas Genet Cytogenet Oncol Haematol. 2012-09-01

Online version: http://atlasgeneticsoncology.org/gene/52851/dpp6-(dipeptidyl-peptidase-like-6)