DAZL (deleted in azoospermia like)

2012-11-01  

Identity

HGNC
DAZL
LOCATION
3p24.3
LOCUSID
1618
ALIAS
DAZH,DAZL1,DAZLA,SPGYLA
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1618
MIM: 601486
HGNC: 2685
Ensembl: ENSG00000092345

Variants:

dbSNP: 1618
ClinVar: 1618
TCGA: ENSG00000092345
COSMIC: DAZL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000092345ENST00000250863Q92904
ENSG00000092345ENST00000399444Q92904
ENSG00000092345ENST00000399444A0A140VK77
ENSG00000092345ENST00000454457E7EV40

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
385889312024A novel cancer-germline gene DAZL promotes progression and cisplatin resistance of non-small cell lung cancer by upregulating JAK2 and MCM8.0
385889312024A novel cancer-germline gene DAZL promotes progression and cisplatin resistance of non-small cell lung cancer by upregulating JAK2 and MCM8.0
364343892023Association of DAZL polymorphisms and DAZ deletion with male infertility: a systematic review and meta-analysis.0
364343892023Association of DAZL polymorphisms and DAZ deletion with male infertility: a systematic review and meta-analysis.0
362738192022DAZL regulates proliferation of human primordial germ cells by direct binding to precursor miRNAs and enhances DICER processing activity.3
362738192022DAZL regulates proliferation of human primordial germ cells by direct binding to precursor miRNAs and enhances DICER processing activity.3
335422612021The marker of alkyl DNA base damage, N7-methylguanine, is associated with semen quality in men.2
346534052021Direct reprogramming of human Sertoli cells into male germline stem cells with the self-renewal and differentiation potentials via overexpressing DAZL/DAZ2/BOULE genes.5
335422612021The marker of alkyl DNA base damage, N7-methylguanine, is associated with semen quality in men.2
346534052021Direct reprogramming of human Sertoli cells into male germline stem cells with the self-renewal and differentiation potentials via overexpressing DAZL/DAZ2/BOULE genes.5
326824092020Suppressing Dazl modulates tumorigenicity and stemness in human glioblastoma cells.9
326824092020Suppressing Dazl modulates tumorigenicity and stemness in human glioblastoma cells.9
283645212017RNA immunoprecipitation identifies novel targets of DAZL in human foetal ovary.14
283882872017In silico analysis of non-synonymous single nucleotide polymorphisms in human DAZL gene associated with male infertility.11
283645212017RNA immunoprecipitation identifies novel targets of DAZL in human foetal ovary.14

Citation

Dessen P

DAZL (deleted in azoospermia like)

Atlas Genet Cytogenet Oncol Haematol. 2012-11-01

Online version: http://atlasgeneticsoncology.org/gene/52990/tumors-explorer/teaching-explorer/meetings