DGKB (diacylglycerol kinase beta)

2012-11-01  

Identity

HGNC
LOCATION
7p21.2
LOCUSID
ALIAS
DAGK2,DGK,DGK-BETA
FUSION GENES

Other Information

Locus ID:

NCBI: 1607
MIM: 604070
HGNC: 2850
Ensembl: ENSG00000136267

Variants:

dbSNP: 1607
ClinVar: 1607
TCGA: ENSG00000136267
COSMIC: DGKB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136267ENST00000399322Q9Y6T7
ENSG00000136267ENST00000402815B5MBY2
ENSG00000136267ENST00000403951Q9Y6T7
ENSG00000136267ENST00000406247Q9Y6T7
ENSG00000136267ENST00000407950B5MCD5
ENSG00000136267ENST00000437998C9JA18

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Glycerolipid metabolismKEGGko00561
Glycerophospholipid metabolismKEGGko00564
Phosphatidylinositol signaling systemKEGGko04070
Glycerolipid metabolismKEGGhsa00561
Glycerophospholipid metabolismKEGGhsa00564
Phosphatidylinositol signaling systemKEGGhsa04070
Metabolic pathwaysKEGGhsa01100
Choline metabolism in cancerKEGGhsa05231
Choline metabolism in cancerKEGGko05231
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Effects of PIP2 hydrolysisREACTOMER-HSA-114508
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128406954Weight gainDiseaseClinicalAnnotationassociatedPD31447353
PA452233antipsychoticsChemicalClinicalAnnotationassociatedPD31447353

References

Pubmed IDYearTitleCitations
200818582010New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.925
173539312007Large-scale mapping of human protein-protein interactions by mass spectrometry.378
201858072010Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans.101
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
208898532011Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.65
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
204194492010Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B loci are associated with reduced glucose-stimulated beta cell function in middle-aged Danish people.43
204904512010Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight.28
205717542010Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population.26
98724521998Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.25

Citation

Dessen P

DGKB (diacylglycerol kinase beta)

Atlas Genet Cytogenet Oncol Haematol. 2012-11-01

Online version: http://atlasgeneticsoncology.org/gene/52993/dgkb-(diacylglycerol-kinase-beta)