PRMT7 (protein arginine methyltransferase 7)

2012-12-01 Affiliation

Identity

HGNC

PRMT7

LOCATION

16q22.1

LOCUSID

54496

ALIAS

SBIDDS

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 54496
MIM: 610087
HGNC: 25557
Ensembl: ENSG00000132600

Variants:

dbSNP: 54496
ClinVar: 54496
TCGA: ENSG00000132600
COSMIC: PRMT7

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000132600	ENST00000339507	Q9NVM4
ENSG00000132600	ENST00000339507	A0A024R726
ENSG00000132600	ENST00000441236	Q9NVM4
ENSG00000132600	ENST00000441236	A0A024R726
ENSG00000132600	ENST00000449359	Q9NVM4
ENSG00000132600	ENST00000562050	H3BTY1
ENSG00000132600	ENST00000562381	H3BRQ9
ENSG00000132600	ENST00000565745	H3BRD3
ENSG00000132600	ENST00000566341	H3BTY1
ENSG00000132600	ENST00000566657	H3BNS2
ENSG00000132600	ENST00000568975	H3BNC0
ENSG00000132600	ENST00000569047	H3BSS9
ENSG00000132600	ENST00000569571	H3BPZ8

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Chromatin organization	REACTOME	R-HSA-4839726
Chromatin modifying enzymes	REACTOME	R-HSA-3247509
RMTs methylate histone arginines	REACTOME	R-HSA-3214858

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
22231400	2012	Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenance.	101
22241471	2012	Human protein arginine methyltransferase 7 (PRMT7) is a type III enzyme forming ω-NG-monomethylated arginine residues.	71
15494416	2005	PRMT7, a new protein arginine methyltransferase that synthesizes symmetric dimethylarginine.	61
15044439	2004	PRMT7 is a member of the protein arginine methyltransferase family with a distinct substrate specificity.	59
17709427	2007	Two distinct arginine methyltransferases are required for biogenesis of Sm-class ribonucleoproteins.	57
22761421	2012	Protein arginine methyltransferase 7 regulates cellular response to DNA damage by methylating promoter histones H2A and H4 of the polymerase δ catalytic subunit gene, POLD1.	41
25136067	2014	PRMT7 induces epithelial-to-mesenchymal transition and promotes metastasis in breast cancer.	38
25605249	2015	Protein arginine methyltransferase 7 promotes breast cancer cell invasion through the induction of MMP9 expression.	19
25294873	2014	Substrate specificity of human protein arginine methyltransferase 7 (PRMT7): the importance of acidic residues in the double E loop.	14
28874563	2017	Epigenetic control via allosteric regulation of mammalian protein arginine methyltransferases.	8

Citation

Dessen P

PRMT7 (protein arginine methyltransferase 7)

Atlas Genet Cytogenet Oncol Haematol. 2012-12-01

Online version: http://atlasgeneticsoncology.org/gene/53107/prmt7-(protein-arginine-methyltransferase-7)