TMED3 (transmembrane p24 trafficking protein 3)

2013-01-01  

Identity

HGNC
LOCATION
15q25.1
LOCUSID
ALIAS
C15orf22,P24B,p24g4,p24gamma4,p26
FUSION GENES

Other Information

Locus ID:

NCBI: 23423
HGNC: 28889
Ensembl: ENSG00000166557

Variants:

dbSNP: 23423
ClinVar: 23423
TCGA: ENSG00000166557
COSMIC: TMED3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166557ENST00000299705Q9Y3Q3
ENSG00000166557ENST00000299705A0A140VKD1
ENSG00000166557ENST00000424155Q9Y3Q3
ENSG00000166557ENST00000536821F5H4M7
ENSG00000166557ENST00000543455G3V1J9

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
COPI-mediated anterograde transportREACTOMER-HSA-6807878
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-dependent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811434

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
249206082014A novel genome-wide in vivo screen for metastatic suppressors in human colon cancer identifies the positive WNT-TCF pathway modulators TMED3 and SOX12.29
227619062012High-throughput transcriptomic and RNAi analysis identifies AIM1, ERGIC1, TMED3 and TPX2 as potential drug targets in prostate cancer.21
279010212016TMED3 promotes hepatocellular carcinoma progression via IL-11/STAT3 signaling.19

Citation

Dessen P

TMED3 (transmembrane p24 trafficking protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2013-01-01

Online version: http://atlasgeneticsoncology.org/gene/53149/tmed3