CAND1 (cullin associated and neddylation dissociated 1)

2013-02-01  

Identity

HGNC
CAND1
LOCATION
12q14.3
LOCUSID
55832
ALIAS
TIP120,TIP120A
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55832
MIM: 607727
HGNC: 30688
Ensembl: ENSG00000111530

Variants:

dbSNP: 55832
ClinVar: 55832
TCGA: ENSG00000111530
COSMIC: CAND1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111530ENST00000540319H0YH27
ENSG00000111530ENST00000540525F5H6I6
ENSG00000111530ENST00000544619A0A0C4DGH5
ENSG00000111530ENST00000545606Q86VP6

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
125040252002NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases.126
125040262002CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex.112
234537572013Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins.91
208201872010miR-148a is an androgen-responsive microRNA that promotes LNCaP prostate cell growth by repressing its target CAND1 expression.50
188269542008SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation.45
126099822003TIP120A associates with cullins and modulates ubiquitin ligase activity.30
223604202012Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.18
230194112012CAND1 promotes PLK4-mediated centriole overduplication and is frequently disrupted in prostate cancer.16
160362202005CAND1 enhances deneddylation of CUL1 by COP9 signalosome.15
212491942011Regulation of cullin RING E3 ubiquitin ligases by CAND1 in vivo.12

Citation

Dessen P

CAND1 (cullin associated and neddylation dissociated 1)

Atlas Genet Cytogenet Oncol Haematol. 2013-02-01

Online version: http://atlasgeneticsoncology.org/gene/53172/cand1-(cullin-associated-and-neddylation-dissociated-1)