KDM2B (lysine demethylase 2B)

2013-03-01  

Identity

HGNC
KDM2B
LOCATION
12q24.31
LOCUSID
84678
ALIAS
CXXC2,FBXL10,Fbl10,JHDM1B,PCCX2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84678
MIM: 609078
HGNC: 13610
Ensembl: ENSG00000089094

Variants:

dbSNP: 84678
ClinVar: 84678
TCGA: ENSG00000089094
COSMIC: KDM2B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000089094ENST00000377069Q8NHM5
ENSG00000089094ENST00000377071Q8NHM5
ENSG00000089094ENST00000446152F8WBN2
ENSG00000089094ENST00000536437F6SRV7
ENSG00000089094ENST00000538046S4R3G4
ENSG00000089094ENST00000538379F5H4A7
ENSG00000089094ENST00000539394F5GXC2
ENSG00000089094ENST00000541318F5H5W7
ENSG00000089094ENST00000541511F5H7T7
ENSG00000089094ENST00000542030F5H4X4
ENSG00000089094ENST00000542973A0A0C4DGG3
ENSG00000089094ENST00000543025F5H0A1
ENSG00000089094ENST00000543852F5GXW2
ENSG00000089094ENST00000545022F5H6N6
ENSG00000089094ENST00000611216Q8NHM5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HDMs demethylate histonesREACTOMER-HSA-3214842

References

Pubmed IDYearTitleCitations
379353022024Transcriptional regulation of amino acid metabolism by KDM2B, in the context of ncPRC1.1 and in concert with MYC and ATF4.2
380171322024The DNA/RNA helicase DHX9 orchestrates the KDM2B-mediated transcriptional regulation of YAP1 in Ewing sarcoma.0
379353022024Transcriptional regulation of amino acid metabolism by KDM2B, in the context of ncPRC1.1 and in concert with MYC and ATF4.2
380171322024The DNA/RNA helicase DHX9 orchestrates the KDM2B-mediated transcriptional regulation of YAP1 in Ewing sarcoma.0
363221512023Delineation of a KDM2B-related neurodevelopmental disorder and its associated DNA methylation signature.4
376348662023KDM2B-Rearranged Soft Tissue Sarcomas Expand the Concept of BCOR-Associated Sarcoma.0
377511352023Biological Functions of the KDM2 Family of Histone Demethylases.1
363221512023Delineation of a KDM2B-related neurodevelopmental disorder and its associated DNA methylation signature.4
376348662023KDM2B-Rearranged Soft Tissue Sarcomas Expand the Concept of BCOR-Associated Sarcoma.0
377511352023Biological Functions of the KDM2 Family of Histone Demethylases.1
353063602022Lysine demethylase 2B regulates angiogenesis via Jumonji C dependent suppression of angiogenic transcription factors.1
355806992022KDM2B mediates the Wnt/β-catenin pathway through transcriptional activation of PKMYT1 via microRNA-let-7b-5p/EZH2 to affect the development of non-small cell lung cancer.2
353063602022Lysine demethylase 2B regulates angiogenesis via Jumonji C dependent suppression of angiogenic transcription factors.1
355806992022KDM2B mediates the Wnt/β-catenin pathway through transcriptional activation of PKMYT1 via microRNA-let-7b-5p/EZH2 to affect the development of non-small cell lung cancer.2
330911892021Inhibition of microRNA let-7b expression by KDM2B promotes cancer progression by targeting EZH2 in ovarian cancer.8

Citation

Dessen P

KDM2B (lysine demethylase 2B)

Atlas Genet Cytogenet Oncol Haematol. 2013-03-01

Online version: http://atlasgeneticsoncology.org/gene/53197/img/deep-insight-explorer/teaching-explorer