MGAT1 (alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase)

2013-03-01  

Identity

HGNC
MGAT1
LOCATION
5q35.3
LOCUSID
4245
ALIAS
GLCNAC-TI,GLCT1,GLYT1,GNT-1,GNT-I,GnTI,MGAT
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4245
MIM: 160995
HGNC: 7044
Ensembl: ENSG00000131446

Variants:

dbSNP: 4245
ClinVar: 4245
TCGA: ENSG00000131446
COSMIC: MGAT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131446ENST00000307826P26572
ENSG00000131446ENST00000333055P26572
ENSG00000131446ENST00000393340P26572
ENSG00000131446ENST00000427865P26572
ENSG00000131446ENST00000446023P26572
ENSG00000131446ENST00000502678D6RBS3
ENSG00000131446ENST00000504671D6RF69
ENSG00000131446ENST00000506269D6R9U2
ENSG00000131446ENST00000506889D6RHZ8
ENSG00000131446ENST00000507384D6RIS2
ENSG00000131446ENST00000512695D6RD15
ENSG00000131446ENST00000513431D6RA48
ENSG00000131446ENST00000514283D6RB69
ENSG00000131446ENST00000514438D6RAK2

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
N-Glycan biosynthesisKEGGko00510
N-Glycan biosynthesisKEGGhsa00510
Metabolic pathwaysKEGGhsa01100
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
N-glycan trimming and elongation in the cis-GolgiREACTOMER-HSA-964739

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
357580242022MicroRNA miR-331-3p suppresses osteosarcoma progression via the Bcl-2/Bax and Wnt/β-Catenin signaling pathways and the epithelial-mesenchymal transition by targeting N-acetylglucosaminyltransferase I (MGAT1).5
357580242022MicroRNA miR-331-3p suppresses osteosarcoma progression via the Bcl-2/Bax and Wnt/β-Catenin signaling pathways and the epithelial-mesenchymal transition by targeting N-acetylglucosaminyltransferase I (MGAT1).5
314949312020N-acetylglucosaminyltransferase I promotes glioma cell proliferation and migration through increasing the stability of the glucose transporter GLUT1.11
327639722020Point mutations that inactivate MGAT4D-L, an inhibitor of MGAT1 and complex N-glycan synthesis.0
314949312020N-acetylglucosaminyltransferase I promotes glioma cell proliferation and migration through increasing the stability of the glucose transporter GLUT1.11
327639722020Point mutations that inactivate MGAT4D-L, an inhibitor of MGAT1 and complex N-glycan synthesis.0
293106262018MGAT1 is a novel transcriptional target of Wnt/β-catenin signaling pathway.8
298535302018Metabolic importance of adipose tissue monoacylglycerol acyltransferase 1 in mice and humans.13
293106262018MGAT1 is a novel transcriptional target of Wnt/β-catenin signaling pathway.8
298535302018Metabolic importance of adipose tissue monoacylglycerol acyltransferase 1 in mice and humans.13
278717642017The rs4285184 polymorphism of the MGAT1 gene as a risk factor for obesity in the Mexican population.1
278717642017The rs4285184 polymorphism of the MGAT1 gene as a risk factor for obesity in the Mexican population.1
267332892016Classical galactosaemia: novel insights in IgG N-glycosylation and N-glycan biosynthesis.21
267332892016Classical galactosaemia: novel insights in IgG N-glycosylation and N-glycan biosynthesis.21
259449012015UDP-galactose (SLC35A2) and UDP-N-acetylglucosamine (SLC35A3) Transporters Form Glycosylation-related Complexes with Mannoside Acetylglucosaminyltransferases (Mgats).21

Citation

Dessen P

MGAT1 (alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase)

Atlas Genet Cytogenet Oncol Haematol. 2013-03-01

Online version: http://atlasgeneticsoncology.org/gene/53198/case-report-explorer/js/web-card-gene.js