CNOT3 (CCR4-NOT transcription complex subunit 3)

2013-04-01  

Identity

HGNC
CNOT3
LOCATION
19q13.42
LOCUSID
4849
ALIAS
IDDSADF,LENG2,NOT3,NOT3H

Other Information

Locus ID:

NCBI: 4849
MIM: 604910
HGNC: 7879
Ensembl: ENSG00000088038

Variants:

dbSNP: 4849
ClinVar: 4849
TCGA: ENSG00000088038
COSMIC: CNOT3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000088038ENST00000221232O75175
ENSG00000088038ENST00000221232A0A024R4R3
ENSG00000088038ENST00000358389O75175
ENSG00000088038ENST00000358389A0A024R4R3
ENSG00000088038ENST00000440571H7C148
ENSG00000088038ENST00000447684H7C3F5
ENSG00000088038ENST00000457463H0Y5X7
ENSG00000088038ENST00000471126H7C5J4
ENSG00000088038ENST00000496327A0A2R8Y691
ENSG00000088038ENST00000613073A0A087X0F9
ENSG00000088038ENST00000617930B7Z6J7
ENSG00000088038ENST00000644245A0A2R8Y7Z8
ENSG00000088038ENST00000646002A0A2R8Y6N5
ENSG00000088038ENST00000647082A0A2R8Y4W0

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
Deadenylation of mRNAREACTOMER-HSA-429947
TP53 Regulates Transcription of Cell Cycle GenesREACTOMER-HSA-6791312
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertainREACTOMER-HSA-6804115

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384910132024Translation efficiency driven by CNOT3 subunit of the CCR4-NOT complex promotes leukemogenesis.0
384910132024Translation efficiency driven by CNOT3 subunit of the CCR4-NOT complex promotes leukemogenesis.0
368023102023Clinical features of CNOT3-associated neurodevelopmental disorder in three Chinese patients.0
378464902023CCR4-NOT differentially controls host versus virus poly(a)-tail length and regulates HCMV infection.3
368023102023Clinical features of CNOT3-associated neurodevelopmental disorder in three Chinese patients.0
378464902023CCR4-NOT differentially controls host versus virus poly(a)-tail length and regulates HCMV infection.3
340736192021A Genetic Study of Cerebral Atherosclerosis Reveals Novel Associations with NTNG1 and CNOT3.2
346137892021CNOT3 interacts with the Aurora B and MAPK/ERK kinases to promote survival of differentiating mesendodermal progenitor cells.0
346809372021Determinants of Disease Penetrance in PRPF31-Associated Retinopathy.6
340736192021A Genetic Study of Cerebral Atherosclerosis Reveals Novel Associations with NTNG1 and CNOT3.2
346137892021CNOT3 interacts with the Aurora B and MAPK/ERK kinases to promote survival of differentiating mesendodermal progenitor cells.0
346809372021Determinants of Disease Penetrance in PRPF31-Associated Retinopathy.6
314747622020The pleiotropy associated with de novo variants in CHD4, CNOT3, and SETD5 extends to moyamoya angiopathy.25
327203252020Inherited cases of CNOT3-associated intellectual developmental disorder with speech delay, autism, and dysmorphic facies.6
314747622020The pleiotropy associated with de novo variants in CHD4, CNOT3, and SETD5 extends to moyamoya angiopathy.25

Citation

Dessen P

CNOT3 (CCR4-NOT transcription complex subunit 3)

Atlas Genet Cytogenet Oncol Haematol. 2013-04-01

Online version: http://atlasgeneticsoncology.org/gene/53235/img/deep-insight-explorer/css/template-nav.css