DCUN1D5 (defective in cullin neddylation 1 domain containing 5)

2013-05-01  

Identity

HGNC
DCUN1D5
LOCATION
11q22.3
LOCUSID
84259
ALIAS
DCNL5,SCCRO5

Other Information

Locus ID:

NCBI: 84259
MIM: 616522
HGNC: 28409
Ensembl: ENSG00000137692

Variants:

dbSNP: 84259
ClinVar: 84259
TCGA: ENSG00000137692
COSMIC: DCUN1D5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137692ENST00000260247Q9BTE7
ENSG00000137692ENST00000260247A0A024R3A2
ENSG00000137692ENST00000525420E9PLH8
ENSG00000137692ENST00000527260H0YCN4
ENSG00000137692ENST00000527576E9PLH8
ENSG00000137692ENST00000527779E9PQV9
ENSG00000137692ENST00000529281E9PLS2
ENSG00000137692ENST00000529294H0YD80
ENSG00000137692ENST00000531543E9PM04
ENSG00000137692ENST00000531571E9PM78
ENSG00000137692ENST00000583974J3QQL8

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
241929282014Oncogenic function of SCCRO5/DCUN1D5 requires its Neddylation E3 activity and nuclear localization.8
230985332012In vitro biological characterization of DCUN1D5 in DNA damage response.2
299582952018The NEDD8 E3 ligase DCNL5 is phosphorylated by IKK alpha during Toll-like receptor activation.1

Citation

Dessen P

DCUN1D5 (defective in cullin neddylation 1 domain containing 5)

Atlas Genet Cytogenet Oncol Haematol. 2013-05-01

Online version: http://atlasgeneticsoncology.org/gene/53255/dcun1d5