SNX5 (sorting nexin 5)

2013-05-01  

Identity

HGNC
SNX5
LOCATION
20p11.23
LOCUSID
27131
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 27131
MIM: 605937
HGNC: 14969
Ensembl: ENSG00000089006

Variants:

dbSNP: 27131
ClinVar: 27131
TCGA: ENSG00000089006
COSMIC: SNX5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000089006ENST00000377759Q9Y5X3
ENSG00000089006ENST00000377768Q9Y5X3
ENSG00000089006ENST00000419004Q5QPE4
ENSG00000089006ENST00000431277Q5QPE5
ENSG00000089006ENST00000463050A0A087WUY5
ENSG00000089006ENST00000481323U3KQL0
ENSG00000089006ENST00000486039U3KQL0
ENSG00000089006ENST00000606557Q9Y5X3
ENSG00000089006ENST00000606557A0A0S2Z5F1
ENSG00000089006ENST00000606602U3KQP5

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
trans-Golgi Network Vesicle BuddingREACTOMER-HSA-199992
Clathrin derived vesicle buddingREACTOMER-HSA-421837
Golgi Associated Vesicle BiogenesisREACTOMER-HSA-432722

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
369775962023The association of lipid transfer protein VPS13A with endosomes is mediated by sorting nexin SNX5.1
369775962023The association of lipid transfer protein VPS13A with endosomes is mediated by sorting nexin SNX5.1
365285562022Overexpression of lncRNA HOXA-AS2 promotes the progression of oral squamous cell carcinoma by mediating SNX5 expression.1
365285562022Overexpression of lncRNA HOXA-AS2 promotes the progression of oral squamous cell carcinoma by mediating SNX5 expression.1
333286392021Sorting nexin 5 mediates virus-induced autophagy and immunity.40
333286392021Sorting nexin 5 mediates virus-induced autophagy and immunity.40
318063682020SNX5 inhibits RLR-mediated antiviral signaling by targeting RIG-I-VISA signalosome.3
318191692020Upregulation of SNX5 predicts poor prognosis and promotes hepatocellular carcinoma progression by modulating the EGFR-ERK1/2 signaling pathway.27
318063682020SNX5 inhibits RLR-mediated antiviral signaling by targeting RIG-I-VISA signalosome.3
318191692020Upregulation of SNX5 predicts poor prognosis and promotes hepatocellular carcinoma progression by modulating the EGFR-ERK1/2 signaling pathway.27
315760582019Molecular identification of a BAR domain-containing coat complex for endosomal recycling of transmembrane proteins.56
315760582019Molecular identification of a BAR domain-containing coat complex for endosomal recycling of transmembrane proteins.56
294449452018Interaction of Human Cytomegalovirus Tegument Proteins ppUL35 and ppUL35A with Sorting Nexin 5 Regulates Glycoprotein B (gpUL55) Localization.14
297433632018Comparative Characterization of the Sindbis Virus Proteome from Mammalian and Invertebrate Hosts Identifies nsP2 as a Component of the Virion and Sorting Nexin 5 as a Significant Host Factor for Alphavirus Replication.14
304190032018The phosphorylation of sorting nexin 5 at serine 226 regulates retrograde transport and macropinocytosis.10

Citation

Dessen P

SNX5 (sorting nexin 5)

Atlas Genet Cytogenet Oncol Haematol. 2013-05-01

Online version: http://atlasgeneticsoncology.org/gene/53258/css/js/js/lib/zoomerang.js