FBXL20 (F-box and leucine rich repeat protein 20)

2013-05-01  

Identity

HGNC
FBXL20
LOCATION
17q12
LOCUSID
84961
ALIAS
Fbl2,Fbl20
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84961
MIM: 609086
HGNC: 24679
Ensembl: ENSG00000108306

Variants:

dbSNP: 84961
ClinVar: 84961
TCGA: ENSG00000108306
COSMIC: FBXL20

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108306ENST00000264658Q96IG2
ENSG00000108306ENST00000394294Q96IG2
ENSG00000108306ENST00000577399J3KTA1
ENSG00000108306ENST00000581781J3QKL3
ENSG00000108306ENST00000583610Q96IG2
ENSG00000108306ENST00000647139A0A2R8Y677

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
363747742023SP1-induced PROX1-AS1 contributes to tumor progression by regulating miR-326/FBXL20 axis in colorectal cancer.1
363747742023SP1-induced PROX1-AS1 contributes to tumor progression by regulating miR-326/FBXL20 axis in colorectal cancer.1
351124622022FBXL20-mediated ubiquitination triggers the proteasomal degradation of 4-1BB.1
351124622022FBXL20-mediated ubiquitination triggers the proteasomal degradation of 4-1BB.1
343389952021F-Box and Leucine-Rich Repeat Protein 20 (FBXL20), Negatively Regulated by microRNA (miR)-195-5p, Accelerates the Malignant Progression of Ovarian Cancer.2
345874752021FBXL20 promotes breast cancer malignancy by inhibiting apoptosis through degradation of PUMA and BAX.4
343389952021F-Box and Leucine-Rich Repeat Protein 20 (FBXL20), Negatively Regulated by microRNA (miR)-195-5p, Accelerates the Malignant Progression of Ovarian Cancer.2
345874752021FBXL20 promotes breast cancer malignancy by inhibiting apoptosis through degradation of PUMA and BAX.4
255933082015FBXL20-mediated Vps34 ubiquitination as a p53 controlled checkpoint in regulating autophagy and receptor degradation.42
255933082015FBXL20-mediated Vps34 ubiquitination as a p53 controlled checkpoint in regulating autophagy and receptor degradation.42
230235842012Role of FBXL20 in human colorectal adenocarcinoma.14
230235842012Role of FBXL20 in human colorectal adenocarcinoma.14
191245062009Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer.27
191245062009Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer.27

Citation

Dessen P

FBXL20 (F-box and leucine rich repeat protein 20)

Atlas Genet Cytogenet Oncol Haematol. 2013-05-01

Online version: http://atlasgeneticsoncology.org/gene/53274/js/js/web-card-gene.js