KLF11 (Kruppel like factor 11)

2013-05-01  

Identity

HGNC
LOCATION
2p25.1
LOCUSID
ALIAS
FKLF,FKLF1,MODY7,TIEG2,Tieg3
FUSION GENES

Other Information

Locus ID:

NCBI: 8462
MIM: 603301
HGNC: 11811
Ensembl: ENSG00000172059

Variants:

dbSNP: 8462
ClinVar: 8462
TCGA: ENSG00000172059
COSMIC: KLF11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172059ENST00000305883O14901
ENSG00000172059ENST00000305883Q53QU8
ENSG00000172059ENST00000401510B5MCC4
ENSG00000172059ENST00000440320C9JM94
ENSG00000172059ENST00000448523E7EX78
ENSG00000172059ENST00000535335O14901
ENSG00000172059ENST00000540845O14901

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

References

Pubmed IDYearTitleCitations
157745812005Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function.71
157745812005Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function.71
255043652015Browning of human adipocytes requires KLF11 and reprogramming of PPARγ superenhancers.58
198435262009MODY7 gene, KLF11, is a novel p300-dependent regulator of Pdx-1 (MODY4) transcription in pancreatic islet beta cells.39
226285452012Mechanistic role for a novel glucocorticoid-KLF11 (TIEG2) protein pathway in stress-induced monoamine oxidase A expression.34
150240152004Dual functions of transcription factors, transforming growth factor-beta-inducible early gene (TIEG)2 and Sp3, are mediated by CACCC element and Sp1 sites of human monoamine oxidase (MAO) B gene.30
201244872010Transcription factor KLF11 integrates progesterone receptor signaling and proliferation in uterine leiomyoma cells.29
215929552011Disruption of a novel Kruppel-like transcription factor p300-regulated pathway for insulin biosynthesis revealed by studies of the c.-331 INS mutation found in neonatal diabetes mellitus.29
229307472012Genome-wide methylation screen in low-grade breast cancer identifies novel epigenetically altered genes as potential biomarkers for tumor diagnosis.29
155315872005KLF11-mediated repression antagonizes Sp1/sterol-responsive element-binding protein-induced transcriptional activation of caveolin-1 in response to cholesterol signaling.28

Citation

Dessen P

KLF11 (Kruppel like factor 11)

Atlas Genet Cytogenet Oncol Haematol. 2013-05-01

Online version: http://atlasgeneticsoncology.org/gene/53276/klf11