UNC119 (unc-119 lipid binding chaperone)

2013-05-01  

Identity

HGNC
UNC119
LOCATION
17q11.2
LOCUSID
9094
ALIAS
HRG4,IMD13,POC7,POC7A
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9094
MIM: 604011
HGNC: 12565
Ensembl: ENSG00000109103

Variants:

dbSNP: 9094
ClinVar: 9094
TCGA: ENSG00000109103
COSMIC: UNC119

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000109103ENST00000301032Q13432
ENSG00000109103ENST00000335765Q13432
ENSG00000109103ENST00000444148C9JSK0
ENSG00000109103ENST00000470125K7EJU3
ENSG00000109103ENST00000484980K7EN86
ENSG00000109103ENST00000581945J3QQT8

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
retina
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
216429722011UNC119 is required for G protein trafficking in sensory neurons.78
229606332012Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119.47
195926522009Uncoordinated 119 protein controls trafficking of Lck via the Rab11 endosome and is critical for immunological synapse formation.36
125273572003Photoreceptor synaptic protein HRG4 (UNC119) interacts with ARL2 via a putative conserved domain.28
124962762003Identification of UNC119 as a novel activator of SRC-type tyrosine kinases.23
217123872011Interaction of transducin with uncoordinated 119 protein (UNC119): implications for the model of transducin trafficking in rod photoreceptors.19
274819432016Novel Biochemical and Structural Insights into the Interaction of Myristoylated Cargo with Unc119 Protein and Their Release by Arl2/3.16
197816302010UNC119 inhibits dynamin and dynamin-dependent endocytic processes.11
208015162011Simultaneous mutation detection in 90 retinal disease genes in multiple patients using a custom-designed 300-kb retinal resequencing chip.11
175790912007Unc119 regulates myofibroblast differentiation through the activation of Fyn and the p38 MAPK pathway.10

Citation

Dessen P

UNC119 (unc-119 lipid binding chaperone)

Atlas Genet Cytogenet Oncol Haematol. 2013-05-01

Online version: http://atlasgeneticsoncology.org/gene/53291/unc119