TNFRSF11A (TNF receptor superfamily member 11a)

2013-05-01 Affiliation

Identity

HGNC

TNFRSF11A

LOCATION

18q21.33

LOCUSID

8792

ALIAS

CD265,FEO,LOH18CR1,ODFR,OFE,OPTB7,OSTS,PDB2,RANK,TRANCE-R,TRANCER

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 8792
MIM: 603499
HGNC: 11908
Ensembl: ENSG00000141655

Variants:

dbSNP: 8792
ClinVar: 8792
TCGA: ENSG00000141655
COSMIC: TNFRSF11A

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000141655	ENST00000269485	Q9Y6Q6
ENSG00000141655	ENST00000586569	Q9Y6Q6
ENSG00000141655	ENST00000616710	Q9Y6Q6
ENSG00000141655	ENST00000617039	Q9Y6Q6
ENSG00000141655	ENST00000639222	A0A1W2PR41

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cytokine-cytokine receptor interaction	KEGG	ko04060
Cytokine-cytokine receptor interaction	KEGG	hsa04060
Osteoclast differentiation	KEGG	ko04380
Osteoclast differentiation	KEGG	hsa04380
Rheumatoid arthritis	KEGG	ko05323
Rheumatoid arthritis	KEGG	hsa05323
NF-kappa B signaling pathway	KEGG	hsa04064
NF-kappa B signaling pathway	KEGG	ko04064
Prolactin signaling pathway	KEGG	hsa04917
Prolactin signaling pathway	KEGG	ko04917
Immune System	REACTOME	R-HSA-168256
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
TNFR2 non-canonical NF-kB pathway	REACTOME	R-HSA-5668541
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	REACTOME	R-HSA-5676594

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA164713217	Pyrazolones	Chemical	ClinicalAnnotation	associated	PD	26398624
PA447216	Schizophrenia	Disease	ClinicalAnnotation	associated	PD
PA448015	acetaminophen	Chemical	ClinicalAnnotation	associated	PD	26398624
PA448497	aspirin	Chemical	ClinicalAnnotation	associated	PD	26398624
PA449293	diclofenac	Chemical	ClinicalAnnotation	associated	PD	26398624
PA451140	propionic acid derivatives	Chemical	ClinicalAnnotation	associated	PD	26398624
PA451257	risperidone	Chemical	ClinicalAnnotation	associated	PD

References

Pubmed ID	Year	Title	Citations
36520195	2023	Familial Paget's disease of bone with ocular manifestations and a novel TNFRSF11A duplication variant (72dup27).	2
36535121	2023	Assessment of RANK/RANK-L prevalence and clinical significance in NSCLC European Thoracic Oncology Platform Lungscape cohort and SPLENDOUR randomized clinical trial.	0
36520195	2023	Familial Paget's disease of bone with ocular manifestations and a novel TNFRSF11A duplication variant (72dup27).	2
36535121	2023	Assessment of RANK/RANK-L prevalence and clinical significance in NSCLC European Thoracic Oncology Platform Lungscape cohort and SPLENDOUR randomized clinical trial.	0
33962883	2022	Receptor Activator of NF Kappa B (RANK) Expression Indicates Favorable Prognosis in Patients with Muscle-invasive Bladder Cancer.	0
35055157	2022	Molecular Mechanisms Leading from Periodontal Disease to Cancer.	13
35163671	2022	Histological Grade and Tumor Stage Are Correlated with Expression of Receptor Activator of Nuclear Factor Kappa b (Rank) in Epithelial Ovarian Cancers.	0
35463988	2022	RANKL Impairs the TLR4 Pathway by Increasing TRAF6 and RANK Interaction in Macrophages.	4
35993046	2022	The Effect of Osteoprotectin (OPG)/Receptor Activator of Nuclear Factor-κB Ligand (RANKL)/Receptor Activator of Nuclear Factor-κB (RANK) Gene Methylation on Aortic Valve Calcified.	0
36589815	2022	The RANK/RANKL/OPG system and tumor bone metastasis: Potential mechanisms and therapeutic strategies.	12
33962883	2022	Receptor Activator of NF Kappa B (RANK) Expression Indicates Favorable Prognosis in Patients with Muscle-invasive Bladder Cancer.	0
35055157	2022	Molecular Mechanisms Leading from Periodontal Disease to Cancer.	13
35163671	2022	Histological Grade and Tumor Stage Are Correlated with Expression of Receptor Activator of Nuclear Factor Kappa b (Rank) in Epithelial Ovarian Cancers.	0
35463988	2022	RANKL Impairs the TLR4 Pathway by Increasing TRAF6 and RANK Interaction in Macrophages.	4
35993046	2022	The Effect of Osteoprotectin (OPG)/Receptor Activator of Nuclear Factor-κB Ligand (RANKL)/Receptor Activator of Nuclear Factor-κB (RANK) Gene Methylation on Aortic Valve Calcified.	0

Citation

Dessen P

TNFRSF11A (TNF receptor superfamily member 11a)

Atlas Genet Cytogenet Oncol Haematol. 2013-05-01

Online version: http://atlasgeneticsoncology.org/gene/53317/teaching-explorer/case-report-explorer/favicon/favicon-16x16.png