MMP7 (matrix metallopeptidase 7)

2013-06-01  

Identity

HGNC
LOCATION
11q22.2
LOCUSID
ALIAS
MMP-7,MPSL1,PUMP-1
FUSION GENES

Other Information

Locus ID:

NCBI: 4316
MIM: 178990
HGNC: 7174
Ensembl: ENSG00000137673

Variants:

dbSNP: 4316
ClinVar: 4316
TCGA: ENSG00000137673
COSMIC: MMP7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137673ENST00000260227P09237

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Wnt signaling pathwayKEGGko04310
Wnt signaling pathwayKEGGhsa04310
Extracellular matrix organizationREACTOMER-HSA-1474244
Collagen formationREACTOMER-HSA-1474290
Assembly of collagen fibrils and other multimeric structuresREACTOMER-HSA-2022090
Degradation of the extracellular matrixREACTOMER-HSA-1474228
Activation of Matrix MetalloproteinasesREACTOMER-HSA-1592389
Collagen degradationREACTOMER-HSA-1442490

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
214817872011Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression.216
119839182002Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans.196
184475762008MMP1 and MMP7 as potential peripheral blood biomarkers in idiopathic pulmonary fibrosis.166
127592412003Matrilysin (matrix metalloproteinase-7) mediates E-cadherin ectodomain shedding in injured lung epithelium.102
237833742013Expression of cilium-associated genes defines novel molecular subtypes of idiopathic pulmonary fibrosis.64
197306832009The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.59
220959472012Matrix metalloproteinase-7 as a surrogate marker predicts renal Wnt/β-catenin activity in CKD.59
162865102005Growth factor-induced shedding of syndecan-1 confers glypican-1 dependence on mitogenic responses of cancer cells.57
194217582009Elevated expressions of MMP7, TROP2, and survivin are associated with survival, disease recurrence, and liver metastasis of colon cancer.57
128080212003Stimulation of MMP-7 (matrilysin) by Helicobacter pylori in human gastric epithelial cells: role in epithelial cell migration.54

Citation

Dessen P

MMP7 (matrix metallopeptidase 7)

Atlas Genet Cytogenet Oncol Haematol. 2013-06-01

Online version: http://atlasgeneticsoncology.org/gene/53331/mmp7