KIF22 (kinesin family member 22)

2013-06-01  

Identity

HGNC
LOCATION
16p11.2
LOCUSID
ALIAS
A-328A3.2,KID,KNSL4,OBP,OBP-1,OBP-2,SEMDJL2
FUSION GENES

Other Information

Locus ID:

NCBI: 3835
MIM: 603213
HGNC: 6391
Ensembl: ENSG00000079616

Variants:

dbSNP: 3835
ClinVar: 3835
TCGA: ENSG00000079616
COSMIC: KIF22

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000079616ENST00000160827Q14807
ENSG00000079616ENST00000400751Q14807
ENSG00000079616ENST00000400751A0A024R632
ENSG00000079616ENST00000561482Q14807
ENSG00000079616ENST00000561482A0A024R632
ENSG00000079616ENST00000568312I3L306
ENSG00000079616ENST00000569382H3BRB3
ENSG00000079616ENST00000569636H3BTH5
ENSG00000079616ENST00000570173H3BQB9

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
MHC class II antigen presentationREACTOMER-HSA-2132295
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231
KinesinsREACTOMER-HSA-983189
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-dependent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811434

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
183293642008Kid-mediated chromosome compaction ensures proper nuclear envelope formation.37
126065722003The human chromokinesin Kid is a plus end-directed microtubule-based motor.24
161769792005The chromokinesin Kid is required for maintenance of proper metaphase spindle size.24
182680992008Importin-beta and the small guanosine triphosphatase Ran mediate chromosome loading of the human chromokinesin Kid.24
221526772011Whole-exome sequencing identifies mutations of KIF22 in spondyloepimetaphyseal dysplasia with joint laxity, leptodactylic type.17
246261462014Inhibition of KIF22 suppresses cancer cell proliferation by delaying mitotic exit through upregulating CDC25C expression.16
126921232003The second microtubule-binding site of monomeric kid enhances the microtubule affinity.14
201442322010Distinct expression patterns of the E3 ligase SIAH-1 and its partner Kid/KIF22 in normal tissues and in the breast tumoral processes.10
221526782011Recurrent dominant mutations affecting two adjacent residues in the motor domain of the monomeric kinesin KIF22 result in skeletal dysplasia and joint laxity.10
177263742007Human Kid is degraded by the APC/C(Cdh1) but not by the APC/C(Cdc20).9

Citation

Dessen P

KIF22 (kinesin family member 22)

Atlas Genet Cytogenet Oncol Haematol. 2013-06-01

Online version: http://atlasgeneticsoncology.org/gene/53339/kif22