IFI6 (interferon alpha inducible protein 6)

2013-06-01  

Identity

HGNC
LOCATION
1p35.3
LOCUSID
ALIAS
6-16,FAM14C,G1P3,IFI-6-16,IFI616
FUSION GENES

Other Information

Locus ID:

NCBI: 2537
MIM: 147572
HGNC: 4054
Ensembl: ENSG00000126709

Variants:

dbSNP: 2537
ClinVar: 2537
TCGA: ENSG00000126709
COSMIC: IFI6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000126709ENST00000339145P09912
ENSG00000126709ENST00000361157P09912
ENSG00000126709ENST00000361157A0A348GSI1
ENSG00000126709ENST00000362020P09912

Expression (GTEx)

0
50
100
150
200
250
300
350
400

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon alpha/beta signalingREACTOMER-HSA-909733

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
367937262023Interferon alpha inducible protein 6 is a negative regulator of innate immune responses by modulating RIG-I activation.10
370671452023The role of glucose-dependent insulinotropic polypeptide 3 (G1P-3) and nucleolar phosphoprotein-1 (NPM1) in pathogenesis of psoriasis.0
376611812023Role of interferon alpha-inducible protein 6 in modulating the proliferation, apoptosis and senescence of oesophageal squamous cell carcinoma cells.1
376703882023BM-MSCs display altered gene expression profiles in B-cell acute lymphoblastic leukemia niches and exert pro-proliferative effects via overexpression of IFI6.1
367937262023Interferon alpha inducible protein 6 is a negative regulator of innate immune responses by modulating RIG-I activation.10
370671452023The role of glucose-dependent insulinotropic polypeptide 3 (G1P-3) and nucleolar phosphoprotein-1 (NPM1) in pathogenesis of psoriasis.0
376611812023Role of interferon alpha-inducible protein 6 in modulating the proliferation, apoptosis and senescence of oesophageal squamous cell carcinoma cells.1
376703882023BM-MSCs display altered gene expression profiles in B-cell acute lymphoblastic leukemia niches and exert pro-proliferative effects via overexpression of IFI6.1
358836852022IDO1, FAT10, IFI6, and GILT Are Involved in the Antiretroviral Activity of γ-Interferon and IDO1 Restricts Retrovirus Infection by Autophagy Enhancement.4
358836852022IDO1, FAT10, IFI6, and GILT Are Involved in the Antiretroviral Activity of γ-Interferon and IDO1 Restricts Retrovirus Infection by Autophagy Enhancement.4
335393402021ATF3 downmodulates its new targets IFI6 and IFI27 to suppress the growth and migration of tongue squamous cell carcinoma cells.14
338682572021The Functional and Antiviral Activity of Interferon Alpha-Inducible IFI6 Against Hepatitis B Virus Replication and Gene Expression.24
335393402021ATF3 downmodulates its new targets IFI6 and IFI27 to suppress the growth and migration of tongue squamous cell carcinoma cells.14
338682572021The Functional and Antiviral Activity of Interferon Alpha-Inducible IFI6 Against Hepatitis B Virus Replication and Gene Expression.24
327275172020IFI6 depletion inhibits esophageal squamous cell carcinoma progression through reactive oxygen species accumulation via mitochondrial dysfunction and endoplasmic reticulum stress.37

Citation

Dessen P

IFI6 (interferon alpha inducible protein 6)

Atlas Genet Cytogenet Oncol Haematol. 2013-06-01

Online version: http://atlasgeneticsoncology.org/gene/53345/js/gene-fusions/css/template-nav.css