GAP43 (growth associated protein 43)

2013-06-01  

Identity

HGNC
LOCATION
3q13.31
LOCUSID
ALIAS
B-50,GAP-43,PP46
FUSION GENES

Other Information

Locus ID:

NCBI: 2596
MIM: 162060
HGNC: 4140
Ensembl: ENSG00000172020

Variants:

dbSNP: 2596
ClinVar: 2596
TCGA: ENSG00000172020
COSMIC: GAP43

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172020ENST00000305124P17677
ENSG00000172020ENST00000305124Q5U058
ENSG00000172020ENST00000393780P17677

Expression (GTEx)

0
100
200
300
400
500
600

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
L1CAM interactionsREACTOMER-HSA-373760

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
211520832010Acyl-protein thioesterase 2 catalyzes the deacylation of peripheral membrane-associated GAP-43.41
233969702013Dynamic palmitoylation links cytosol-membrane shuttling of acyl-protein thioesterase-1 and acyl-protein thioesterase-2 with that of proto-oncogene H-ras product and growth-associated protein-43.33
121052192002Mass spectrometric analysis of GAP-43/neuromodulin reveals the presence of a variety of fatty acylated species.29
175776682007Coordinated expression of HuD and GAP-43 in hippocampal dentate granule cells during developmental and adult plasticity.19
176190162007Functional cooperation between TrkA and p75(NTR) accelerates neuronal differentiation by increased transcription of GAP-43 and p21(CIP/WAF) genes via ERK1/2 and AP-1 activities.13
276044092016CSF profiling of the human brain enriched proteome reveals associations of neuromodulin and neurogranin to Alzheimer's disease.13
156942362005Growth-associated protein 43 (GAP-43) and synaptophysin alterations in the dentate gyrus of patients with schizophrenia.11
257552782015Protein kinase C-dependent growth-associated protein 43 phosphorylation regulates gephyrin aggregation at developing GABAergic synapses.9
274893082016Copy-number variations are enriched for neurodevelopmental genes in children with developmental coordination disorder.9

Citation

Dessen P

GAP43 (growth associated protein 43)

Atlas Genet Cytogenet Oncol Haematol. 2013-06-01

Online version: http://atlasgeneticsoncology.org/gene/53398/gap43