ATG10 (autophagy related 10)

2013-07-01  

Identity

HGNC
ATG10
LOCATION
5q14.1
LOCUSID
83734
ALIAS
APG10,APG10L,pp12616
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 83734
MIM: 610800
HGNC: 20315
Ensembl: ENSG00000152348

Variants:

dbSNP: 83734
ClinVar: 83734
TCGA: ENSG00000152348
COSMIC: ATG10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152348ENST00000282185Q9H0Y0
ENSG00000152348ENST00000355178Q9H0Y0
ENSG00000152348ENST00000355178A0A024RAK8
ENSG00000152348ENST00000458350Q9H0Y0
ENSG00000152348ENST00000504770D6RBD1
ENSG00000152348ENST00000510085D6RC89
ENSG00000152348ENST00000513443Q9H0Y0
ENSG00000152348ENST00000513443A0A024RAK8
ENSG00000152348ENST00000513634D6RDX3

Expression (GTEx)

0
1
2
3
4
5
6
7
8
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
Autophagy - animalKEGGhsa04140
Cellular responses to stressREACTOMER-HSA-2262752
MacroautophagyREACTOMER-HSA-1632852
Autophagy - otherKEGGko04136
Autophagy - otherKEGGhsa04136

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
232851622012Increased expression of ATG10 in colorectal cancer is associated with lymphovascular invasion and lymph node metastasis.21
278367352017Polypyrimidine tract-binding protein 1-mediated down-regulation of ATG10 facilitates metastasis of colorectal cancer cells.14
238505772013Potentially functional polymorphisms in ATG10 are associated with risk of breast cancer in a Chinese population.13
261517732015Burkholderia pseudomallei survival in lung epithelial cells benefits from miRNA-mediated suppression of ATG10.10
272253072016Role of ATG10 expression quantitative trait loci in non-small cell lung cancer survival.9
289001562017Dual Roles of Two Isoforms of Autophagy-related Gene ATG10 in HCV-Subgenomic replicon Mediated Autophagy Flux and Innate Immunity.8
303196332018Differential Effects of Autophagy-Related 10 Protein on HCV Replication and Autophagy Flux Are Mediated by Its Cysteine44 and Cysteine135.3
312980382019Long noncoding RNA HAGLROS regulates apoptosis and autophagy in Parkinson's disease via regulating miR-100/ATG10 axis and PI3K/Akt/mTOR pathway activation.3
276393332017Gelatin scaffold combined with bone morphogenetic protein-4 induces odontoblast-like cell differentiation involving integrin profile changes, autophagy-related gene 10, and Wnt5 sequentially in human induced pluripotent stem cells.1

Citation

Dessen P

ATG10 (autophagy related 10)

Atlas Genet Cytogenet Oncol Haematol. 2013-07-01

Online version: http://atlasgeneticsoncology.org/gene/53439/atg10