GABARAPL2 (GABA type A receptor associated protein like 2)

2013-07-01  

Identity

HGNC
LOCATION
16q23.1
LOCUSID
ALIAS
ATG8,ATG8C,GATE-16,GATE16,GEF-2,GEF2
FUSION GENES

Other Information

Locus ID:

NCBI: 11345
MIM: 607452
HGNC: 13291
Ensembl: ENSG00000034713

Variants:

dbSNP: 11345
ClinVar: 11345
TCGA: ENSG00000034713
COSMIC: GABARAPL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000034713ENST00000037243P60520
ENSG00000034713ENST00000563744H3BU36
ENSG00000034713ENST00000565057H3BSM5
ENSG00000034713ENST00000568455H3BQ50

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
Autophagy - animalKEGGhsa04140
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
GABAergic synapseKEGGko04727
GABAergic synapseKEGGhsa04727
FoxO signaling pathwayKEGGhsa04068
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Cellular responses to stressREACTOMER-HSA-2262752
MacroautophagyREACTOMER-HSA-1632852
TBC/RABGAPsREACTOMER-HSA-8854214
Apelin signaling pathwayKEGGhsa04371
Mitophagy - animalKEGGko04137
Mitophagy - animalKEGGhsa04137
Autophagy - otherKEGGko04136
Autophagy - otherKEGGhsa04136

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
187687532008The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice.168
231122932012The Legionella effector RavZ inhibits host autophagy through irreversible Atg8 deconjugation.151
230431072012ATG8 family proteins act as scaffolds for assembly of the ULK complex: sequence requirements for LC3-interacting region (LIR) motifs.111
214977582011LC3 and GATE-16 N termini mediate membrane fusion processes required for autophagosome biogenesis.105
228855982012Binding of the Atg1/ULK1 kinase to the ubiquitin-like protein Atg8 regulates autophagy.100
223549922012Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers.76
211778652011Kinetics comparisons of mammalian Atg4 homologues indicate selective preferences toward diverse Atg8 substrates.74
247474382014Lipidation of the LC3/GABARAP family of autophagy proteins relies on a membrane-curvature-sensing domain in Atg3.72
163037672006Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16.67
224219682012TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death.49

Citation

Dessen P

GABARAPL2 (GABA type A receptor associated protein like 2)

Atlas Genet Cytogenet Oncol Haematol. 2013-07-01

Online version: http://atlasgeneticsoncology.org/gene/53460/gabarapl2