BAIAP2L1 (BAR/IMD domain containing adaptor protein 2 like 1)

2013-07-01  

Identity

HGNC
LOCATION
7q21.3
LOCUSID
ALIAS
IRTKS
FUSION GENES

Other Information

Locus ID:

NCBI: 55971
MIM: 611877
HGNC: 21649
Ensembl: ENSG00000006453

Variants:

dbSNP: 55971
ClinVar: 55971
TCGA: ENSG00000006453
COSMIC: BAIAP2L1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000006453ENST00000005260Q9UHR4

Expression (GTEx)

0
10
20
30
40
50
60

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
231754432013Oncogenic FGFR3 gene fusions in bladder cancer.129
193666622009Insulin receptor tyrosine kinase substrate links the E. coli O157:H7 actin assembly effectors Tir and EspF(U) during pedestal formation.54
174309762007Characterisation of IRTKS, a novel IRSp53/MIM family actin regulator with distinct filament bundling properties.37
210982792010Recognition of tandem PxxP motifs as a unique Src homology 3-binding mode triggers pathogen-driven actin assembly.25
255894962015Mechanism of Oncogenic Signal Activation by the Novel Fusion Kinase FGFR3-BAIAP2L1.14
236930782013Insulin receptor tyrosine kinase substrate activates EGFR/ERK signalling pathway and promotes cell proliferation of hepatocellular carcinoma.12
218403122011Src-stimulated IRTKS phosphorylation enhances cell migration.7
301970892018IRTKS (BAIAP2L1) Elongates Epithelial Microvilli Using EPS8-Dependent and Independent Mechanisms.7
272780192016The Rho GTPase Rif signals through IRTKS, Eps8 and WAVE2 to generate dorsal membrane ruffles and filopodia.6
218872752011Insulin receptor tyrosine kinase substrate enhances low levels of MDM2-mediated p53 ubiquitination.5

Citation

Dessen P

BAIAP2L1 (BAR/IMD domain containing adaptor protein 2 like 1)

Atlas Genet Cytogenet Oncol Haematol. 2013-07-01

Online version: http://atlasgeneticsoncology.org/gene/53465/baiap2l1