IL13RA1 (interleukin 13 receptor subunit alpha 1)

2013-08-01  

Identity

HGNC
IL13RA1
LOCATION
Xq24
LOCUSID
3597
ALIAS
CD213A1,CT19,IL-13Ra,NR4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3597
MIM: 300119
HGNC: 5974
Ensembl: ENSG00000131724

Variants:

dbSNP: 3597
ClinVar: 3597
TCGA: ENSG00000131724
COSMIC: IL13RA1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131724ENST00000371642P78552
ENSG00000131724ENST00000371666P78552
ENSG00000131724ENST00000652600A0A494C1C4

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Jak-STAT signaling pathwayKEGGko04630
Cytokine-cytokine receptor interactionKEGGhsa04060
Jak-STAT signaling pathwayKEGGhsa04630
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807

References

Pubmed IDYearTitleCitations
210975052011The interleukin 13 (IL-13) pathway in human macrophages is modulated by microRNA-155 via direct targeting of interleukin 13 receptor alpha1 (IL13Ralpha1).106
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
261873312015Commentary: IL-4 and IL-13 receptors and signaling.39
212364782011Human TH17 cells express a functional IL-13 receptor and IL-13 attenuates IL-17A production.35
260887532015Targeting of IL-4 and IL-13 receptors for cancer therapy.35
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
192589232009Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.26
196549412009Interleukin-13 and its receptors in idiopathic interstitial pneumonia: clinical implications for lung function.26
158700682005Characterization of the interaction between interleukin-13 and interleukin-13 receptors.24

Citation

Dessen P

IL13RA1 (interleukin 13 receptor subunit alpha 1)

Atlas Genet Cytogenet Oncol Haematol. 2013-08-01

Online version: http://atlasgeneticsoncology.org/gene/53486/il13ra1