ME1 (malic enzyme 1)

2013-09-01  

Identity

HGNC
LOCATION
6q14.2
LOCUSID
ALIAS
HUMNDME,MES
FUSION GENES

Other Information

Locus ID:

NCBI: 4199
MIM: 154250
HGNC: 6983
Ensembl: ENSG00000065833

Variants:

dbSNP: 4199
ClinVar: 4199
TCGA: ENSG00000065833
COSMIC: ME1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000065833ENST00000369705P48163

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Pyruvate metabolismKEGGko00620
PPAR signaling pathwayKEGGko03320
Pyruvate metabolismKEGGhsa00620
PPAR signaling pathwayKEGGhsa03320
Metabolic pathwaysKEGGhsa01100
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
233344212013Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence.143
215555182011The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.60
186604892008Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.26
192933342009Role for malic enzyme, pyruvate carboxylation, and mitochondrial malate import in glucose-stimulated insulin secretion.22
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
257534782015Malic enzyme 1 induces epithelial-mesenchymal transition and indicates poor prognosis in hepatocellular carcinoma.17
113528552001The interaction between microsomal epoxide hydrolase polymorphisms and cumulative cigarette smoking in different histological subtypes of lung cancer.15
296541552018ME1 Regulates NADPH Homeostasis to Promote Gastric Cancer Growth and Metastasis.14
261737802015Mutant KRAS associated malic enzyme 1 expression is a predictive marker for radiation therapy response in non-small cell lung cancer.13
231140902012Repressing malic enzyme 1 redirects glucose metabolism, unbalances the redox state, and attenuates migratory and invasive abilities in nasopharyngeal carcinoma cell lines.12

Citation

Dessen P

ME1 (malic enzyme 1)

Atlas Genet Cytogenet Oncol Haematol. 2013-09-01

Online version: http://atlasgeneticsoncology.org/gene/53518/me1-(malic-enzyme-1)