HNRNPC (heterogeneous nuclear ribonucleoprotein C)

2013-11-01  

Identity

HGNC
HNRNPC
LOCATION
14q11.2
LOCUSID
3183
ALIAS
C1,C2,HNRNP,HNRPC,SNRPC
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3183
MIM: 164020
HGNC: 5035
Ensembl: ENSG00000092199

Variants:

dbSNP: 3183
ClinVar: 3183
TCGA: ENSG00000092199
COSMIC: HNRNPC

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000092199ENST00000336053B4DY08
ENSG00000092199ENST00000420743P07910
ENSG00000092199ENST00000430246P07910
ENSG00000092199ENST00000449098B2R5W2
ENSG00000092199ENST00000553300P07910
ENSG00000092199ENST00000553753B4DY08
ENSG00000092199ENST00000554383G3V4W0
ENSG00000092199ENST00000554455P07910
ENSG00000092199ENST00000554539G3V5V7
ENSG00000092199ENST00000554891G3V251
ENSG00000092199ENST00000554969P07910
ENSG00000092199ENST00000555137G3V555
ENSG00000092199ENST00000555176G3V5X6
ENSG00000092199ENST00000555215G3V575
ENSG00000092199ENST00000555309G3V2Q1
ENSG00000092199ENST00000555883P07910
ENSG00000092199ENST00000555914G3V4C1
ENSG00000092199ENST00000556142G3V576
ENSG00000092199ENST00000556226G3V3K6
ENSG00000092199ENST00000556513G3V576
ENSG00000092199ENST00000556628P07910
ENSG00000092199ENST00000556897P07910
ENSG00000092199ENST00000557157G3V2D6
ENSG00000092199ENST00000557201P07910
ENSG00000092199ENST00000557336G3V4M8
ENSG00000092199ENST00000557442B4DSU6
ENSG00000092199ENST00000557768G3V2H6

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
SUMO E3 ligases SUMOylate target proteinsREACTOMER-HSA-3108232
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163
SUMOylation of RNA binding proteinsREACTOMER-HSA-4570464

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382176752024Hsa_circ_0014606 Derived from Exosomes Promotes Gastric Carcinoma Tumorigenesis and Proliferation by Sponging miR-514b-3p to Upregulate HNRNPC.1
382993192024N6-Methyladenosine reader HNRNPC-mediated downregulation of circITCH prevents miR-224-3p sequestering and contributes to tumorigenesis in nasopharyngeal carcinoma.2
383533592024HNRNPC promotes estrogen receptor-positive breast cancer cell cycle by stabilizing WDR77 mRNA in an m6A-dependent manner.1
385140682024HNRNPC Regulates GLUT1/LDHA Pathway by Stabilizing FOXM1 mRNA to Promote the Progression and Aerobic Glycolysis of Multiple Myeloma.0
385385362024DUSP3 modulates IRES-dependent translation of mRNAs through dephosphorylation of the HNRNPC protein in cells under genotoxic stimulus.0
389489302024Identification of RNA-binding protein hnRNP C targeting the 3'UTR of the TAP-associated glycoprotein tapasin in melanoma.0
382176752024Hsa_circ_0014606 Derived from Exosomes Promotes Gastric Carcinoma Tumorigenesis and Proliferation by Sponging miR-514b-3p to Upregulate HNRNPC.1
382993192024N6-Methyladenosine reader HNRNPC-mediated downregulation of circITCH prevents miR-224-3p sequestering and contributes to tumorigenesis in nasopharyngeal carcinoma.2
383533592024HNRNPC promotes estrogen receptor-positive breast cancer cell cycle by stabilizing WDR77 mRNA in an m6A-dependent manner.1
385140682024HNRNPC Regulates GLUT1/LDHA Pathway by Stabilizing FOXM1 mRNA to Promote the Progression and Aerobic Glycolysis of Multiple Myeloma.0
385385362024DUSP3 modulates IRES-dependent translation of mRNAs through dephosphorylation of the HNRNPC protein in cells under genotoxic stimulus.0
389489302024Identification of RNA-binding protein hnRNP C targeting the 3'UTR of the TAP-associated glycoprotein tapasin in melanoma.0
366813552023N6-methylation of RNA-bound adenosine regulator HNRNPC promotes vascular endothelial dysfunction in type 2 diabetes mellitus by activating the PSEN1-mediated Notch pathway.2
367189502023HNRNPC suppresses tumor immune microenvironment by activating Treg cells promoting the progression of prostate cancer.7
373711032023HnRNP Pathologies in Frontotemporal Lobar Degeneration.0

Citation

Dessen P

HNRNPC (heterogeneous nuclear ribonucleoprotein C)

Atlas Genet Cytogenet Oncol Haematol. 2013-11-01

Online version: http://atlasgeneticsoncology.org/gene/53547/favicon/js/lib/bootstrap.min.js