CDYL (chromodomain Y like)

2013-11-01  

Identity

HGNC
CDYL
LOCATION
6p25.1
LOCUSID
9425
ALIAS
CDYL1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9425
MIM: 603778
HGNC: 1811
Ensembl: ENSG00000153046

Variants:

dbSNP: 9425
ClinVar: 9425
TCGA: ENSG00000153046
COSMIC: CDYL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000153046ENST00000328908Q9Y232
ENSG00000153046ENST00000343762Q9Y232
ENSG00000153046ENST00000397588Q9Y232
ENSG00000153046ENST00000440139C9JQG7
ENSG00000153046ENST00000449732Q9Y232

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
190616462008CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation.65
197306832009The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.59
288037792017Chromodomain Protein CDYL Acts as a Crotonyl-CoA Hydratase to Regulate Histone Crotonylation and Spermatogenesis.27
198086722009Multimerization and H3K9me3 binding are required for CDYL1b heterochromatin association.25
220097392011Corepressor protein CDYL functions as a molecular bridge between polycomb repressor complex 2 and repressive chromatin mark trimethylated histone lysine 27.24
246719952014Coordinated regulation of dendrite arborization by epigenetic factors CDYL and EZH2.17
291774812018CDYL1 fosters double-strand break-induced transcription silencing and promotes homology-directed repair.9
284024392017Chromodomain protein CDYL is required for transmission/restoration of repressive histone marks.5
236299482013Short-Form CDYLb but not long-form CDYLa functions cooperatively with histone methyltransferase G9a in hepatocellular carcinomas.4
300094872018Genome-wide association study: Exploring the genetic basis for responsiveness to ketogenic dietary therapies for drug-resistant epilepsy.3

Citation

Dessen P

CDYL (chromodomain Y like)

Atlas Genet Cytogenet Oncol Haematol. 2013-11-01

Online version: http://atlasgeneticsoncology.org/gene/53565/cdyl-(chromodomain-y-like)