CCL1 (C-C motif chemokine ligand 1)

2013-11-01  

Identity

HGNC
LOCATION
17q12
LOCUSID
ALIAS
I-309,P500,SCYA1,SISe,TCA3

Other Information

Locus ID:

NCBI: 6346
MIM: 182281
HGNC: 10609
Ensembl: ENSG00000108702

Variants:

dbSNP: 6346
ClinVar: 6346
TCGA: ENSG00000108702
COSMIC: CCL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108702ENST00000225842P22362

Expression (GTEx)

0
1

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Chemokine receptors bind chemokinesREACTOMER-HSA-380108

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
129492492003Many chemokines including CCL20/MIP-3alpha display antimicrobial activity.154
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
238783092013Tumor cell entry into the lymph node is controlled by CCL1 chemokine expressed by lymph node lymphatic sinuses.66
190576612008Identification of tuberculosis susceptibility genes with human macrophage gene expression profiles.55
167356932006Differential regulation of chemokine production by Fcgamma receptor engagement in human monocytes: association of CCL1 with a distinct form of M2 monocyte activation (M2b, Type 2).54
158147392005CCL1-CCR8 interactions: an axis mediating the recruitment of T cells and Langerhans-type dendritic cells to sites of atopic skin inflammation.48
166793172006Aryl hydrocarbon receptor- and calcium-dependent induction of the chemokine CCL1 by the environmental contaminant benzo[a]pyrene.32
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
192589232009Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.26
176410402007Coordinated involvement of mast cells and T cells in allergic mucosal inflammation: critical role of the CC chemokine ligand 1:CCR8 axis.24

Citation

Dessen P

CCL1 (C-C motif chemokine ligand 1)

Atlas Genet Cytogenet Oncol Haematol. 2013-11-01

Online version: http://atlasgeneticsoncology.org/gene/53596/ccl1-(c-c-motif-chemokine-ligand-1)