TRIT1 (tRNA isopentenyltransferase 1)

2013-11-01  

Identity

HGNC
LOCATION
1p34.2
LOCUSID
ALIAS
COXPD35,GRO1,IPPT,IPT,IPTase,MOD5,hGRO1
FUSION GENES

Other Information

Locus ID:

NCBI: 54802
MIM: 617840
HGNC: 20286
Ensembl: ENSG00000043514

Variants:

dbSNP: 54802
ClinVar: 54802
TCGA: ENSG00000043514
COSMIC: TRIT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000043514ENST00000316891Q9H3H1
ENSG00000043514ENST00000372818Q9H3H1
ENSG00000043514ENST00000441669Q9H3H1
ENSG00000043514ENST00000462797S4R2Z0
ENSG00000043514ENST00000469476S4R3U8
ENSG00000043514ENST00000486825S4R3C5
ENSG00000043514ENST00000489945B4DK89
ENSG00000043514ENST00000492612S4R2X1
ENSG00000043514ENST00000495175S4R3F4
ENSG00000043514ENST00000537440Q9H3H1
ENSG00000043514ENST00000541099Q3T7B4
ENSG00000043514ENST00000648678A0A3B3ITK2

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Metabolic pathwaysKEGGhsa01100
Gene ExpressionREACTOMER-HSA-74160
tRNA processingREACTOMER-HSA-72306
tRNA modification in the nucleus and cytosolREACTOMER-HSA-6782315
tRNA modification in the mitochondrionREACTOMER-HSA-6787450

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
249013672014Defective i6A37 modification of mitochondrial and cytosolic tRNAs results from pathogenic mutations in TRIT1 and its substrate tRNA.46
241260542013Human cells have a limited set of tRNA anticodon loop substrates of the tRNA isopentenyltransferase TRIT1 tumor suppressor.21
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
200958542010Novel breast cancer risk alleles and interaction with ionizing radiation among U.S. radiologic technologists.16
171450942007Ethnic differences in frequencies of gene polymorphisms in the MYCL1 region and modulation of lung cancer patients' survival.11
171450942007Ethnic differences in frequencies of gene polymorphisms in the MYCL1 region and modulation of lung cancer patients' survival.11
281853762017Matchmaking facilitates the diagnosis of an autosomal-recessive mitochondrial disease caused by biallelic mutation of the tRNA isopentenyltransferase (TRIT1) gene.9
252618502015The cytoplasmic and nuclear populations of the eukaryote tRNA-isopentenyl transferase have distinct functions with implications in human cancer.8
233490192013Association of polymorphisms and haplotype in the region of TRIT1, MYCL1 and MFSD2A with the risk and clinicopathological features of gastric cancer in a southeast Chinese population.6

Citation

Dessen P

TRIT1 (tRNA isopentenyltransferase 1)

Atlas Genet Cytogenet Oncol Haematol. 2013-11-01

Online version: http://atlasgeneticsoncology.org/gene/53605/trit1