HELQ (helicase, POLQ like)

2014-03-01  

Identity

HGNC
LOCATION
4q21.23
LOCUSID
ALIAS
HEL308
FUSION GENES

Other Information

Locus ID:

NCBI: 113510
MIM: 606769
HGNC: 18536
Ensembl: ENSG00000163312

Variants:

dbSNP: 113510
ClinVar: 113510
TCGA: ENSG00000163312
COSMIC: HELQ

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163312ENST00000295488Q8TDG4
ENSG00000163312ENST00000508591E3W982
ENSG00000163312ENST00000510985E3W980

Expression (GTEx)

0
5
10
15
20
25

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
385403912024A Human Homozygous HELQ Missense Variant Does Not Cause Premature Ovarian Insufficiency in a Mouse Model.0
387204712024HELQ deficiency impairs the induction of primordial germ cell-like cells.0
385403912024A Human Homozygous HELQ Missense Variant Does Not Cause Premature Ovarian Insufficiency in a Mouse Model.0
387204712024HELQ deficiency impairs the induction of primordial germ cell-like cells.0
367189392023Interaction of human HelQ with DNA polymerase delta halts DNA synthesis and stimulates DNA single-strand annealing.3
377771522023Mitotic DNA Synthesis in Untransformed Human Cells Preserves Common Fragile Site Stability via a FANCD2-Driven Mechanism That Requires HELQ.1
378973542023Human HELQ regulates DNA end resection at DNA double-strand breaks and stalled replication forks.0
367189392023Interaction of human HelQ with DNA polymerase delta halts DNA synthesis and stimulates DNA single-strand annealing.3
377771522023Mitotic DNA Synthesis in Untransformed Human Cells Preserves Common Fragile Site Stability via a FANCD2-Driven Mechanism That Requires HELQ.1
378973542023Human HELQ regulates DNA end resection at DNA double-strand breaks and stalled replication forks.0
334853492021HELQ and EGR3 expression correlate with IGHV mutation status and prognosis in chronic lymphocytic leukemia.3
346727752021Identification and Functional Investigation of Novel Heterozygous HELQ Mutations in Patients with Sertoli Cell-only Syndrome.3
334853492021HELQ and EGR3 expression correlate with IGHV mutation status and prognosis in chronic lymphocytic leukemia.3
346727752021Identification and Functional Investigation of Novel Heterozygous HELQ Mutations in Patients with Sertoli Cell-only Syndrome.3
295720312018Helicase POLQ-like (HELQ) as a novel indicator of platinum-based chemoresistance for epithelial ovarian cancer.8

Citation

Dessen P

HELQ (helicase, POLQ like)

Atlas Genet Cytogenet Oncol Haematol. 2014-03-01

Online version: http://atlasgeneticsoncology.org/gene/53819/meetings/gene-fusions-explorer/favicon/favicon-32x32.png