STAB2 (stabilin 2)

2014-04-01  

Identity

HGNC
LOCATION
12q23.3
LOCUSID
ALIAS
FEEL2,FELE-2,FELL2,FEX2,HARE,SCARH1
FUSION GENES

Other Information

Locus ID:

NCBI: 55576
MIM: 608561
HGNC: 18629
Ensembl: ENSG00000136011

Variants:

dbSNP: 55576
ClinVar: 55576
TCGA: ENSG00000136011
COSMIC: STAB2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136011ENST00000388887Q8WWQ8
ENSG00000136011ENST00000549474H0YIF3
ENSG00000136011ENST00000552777H0YHA5

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Binding and Uptake of Ligands by Scavenger ReceptorsREACTOMER-HSA-2173782
Scavenging by Class H ReceptorsREACTOMER-HSA-3000497
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glycosaminoglycan metabolismREACTOMER-HSA-1630316
Hyaluronan metabolismREACTOMER-HSA-2142845
Hyaluronan uptake and degradationREACTOMER-HSA-2160916

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
179628162008Rapid cell corpse clearance by stabilin-2, a membrane phosphatidylserine receptor.166
118297522002Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues.75
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
184343172008The human hyaluronan receptor for endocytosis (HARE/Stabilin-2) is a systemic clearance receptor for heparin.53
171457552007Expression, processing, and glycosaminoglycan binding activity of the recombinant human 315-kDa hyaluronic acid receptor for endocytosis (HARE).44
182306082008Requirement of adaptor protein GULP during stabilin-2-mediated cell corpse engulfment.38
185738702008Epidermal growth factor-like domain repeat of stabilin-2 recognizes phosphatidylserine during cell corpse clearance.35
225666882012Cross talk between engulfment receptors stabilin-2 and integrin αvβ5 orchestrates engulfment of phosphatidylserine-exposed erythrocytes.34
184998642008The ligand-binding profile of HARE: hyaluronan and chondroitin sulfates A, C, and D bind to overlapping sites distinct from the sites for heparin, acetylated low-density lipoprotein, dermatan sulfate, and CS-E.33
235300332013The hyaluronan receptor for endocytosis (HARE) activates NF-κB-mediated gene expression in response to 40-400-kDa, but not smaller or larger, hyaluronans.30

Citation

Dessen P

STAB2 (stabilin 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-04-01

Online version: http://atlasgeneticsoncology.org/gene/53867/stab2-(stabilin-2)