ZNRF3 (zinc and ring finger 3)

2014-05-01  

Identity

HGNC
LOCATION
22q12.1
LOCUSID
ALIAS
BK747E2.3,RNF203
FUSION GENES

Other Information

Locus ID:

NCBI: 84133
MIM: 612062
HGNC: 18126
Ensembl: ENSG00000183579

Variants:

dbSNP: 84133
ClinVar: 84133
TCGA: ENSG00000183579
COSMIC: ZNRF3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183579ENST00000402174Q9ULT6
ENSG00000183579ENST00000406323Q9ULT6
ENSG00000183579ENST00000544604Q9ULT6
ENSG00000183579ENST00000544604A0A024R1J1

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Regulation of FZD by ubiquitinationREACTOMER-HSA-4641263

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
209356292010Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.396
225759592012ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner.252
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
258910772015Dishevelled promotes Wnt receptor degradation through recruitment of ZNRF3/RNF43 E3 ubiquitin ligases.46
242257762013Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin.41
276611072016RNF43 and ZNRF3 are commonly altered in serrated pathway colorectal tumorigenesis.27
297697202018RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6.24
243494402013Structures of Wnt-antagonist ZNRF3 and its complex with R-spondin 1 and implications for signaling.18
297357152018ZNRF3 functions in mammalian sex determination by inhibiting canonical WNT signaling.16
235042002013ZNRF3 acts as a tumour suppressor by the Wnt signalling pathway in human gastric adenocarcinoma.15

Citation

Dessen P

ZNRF3 (zinc and ring finger 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-05-01

Online version: http://atlasgeneticsoncology.org/gene/53896/znrf3