APOL2 (apolipoprotein L2)

2014-01-01  

Identity

HGNC
APOL2
LOCATION
22q12.3
LOCUSID
23780
ALIAS
APOL-II,APOL3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23780
MIM: 607252
HGNC: 619
Ensembl: ENSG00000128335

Variants:

dbSNP: 23780
ClinVar: 23780
TCGA: ENSG00000128335
COSMIC: APOL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128335ENST00000249066Q9BQE5
ENSG00000128335ENST00000249066A0A024R1M8
ENSG00000128335ENST00000358502Q9BQE5
ENSG00000128335ENST00000358502A0A024R1M8
ENSG00000128335ENST00000451256J3KQL8
ENSG00000128335ENST00000454728B0QYK8
ENSG00000128335ENST00000529194E9PM95

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
119449862002The apolipoprotein L gene cluster has emerged recently in evolution and is expressed in human vascular tissue.61
249010462014Apolipoprotein L2 contains a BH3-like domain but it does not behave as a BH3-only protein.12
186322552008Association of SNPs and haplotypes in APOL1, 2 and 4 with schizophrenia.11
186322552008Association of SNPs and haplotypes in APOL1, 2 and 4 with schizophrenia.11
206657052011A novel anti-apoptotic role for apolipoprotein L2 in IFN-γ-induced cytotoxicity in human bronchial epithelial cells.6
159496552005Investigation of the apolipoprotein-L (APOL) gene family and schizophrenia using a novel DNA pooling strategy for public database SNPs.5
206026152010Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?2

Citation

Dessen P

APOL2 (apolipoprotein L2)

Atlas Genet Cytogenet Oncol Haematol. 2014-01-01

Online version: http://atlasgeneticsoncology.org/gene/53919/apol2-(apolipoprotein-l2)