DDAH1 (dimethylarginine dimethylaminohydrolase 1)

2014-06-01  

Identity

HGNC
LOCATION
1p22.3
LOCUSID
ALIAS
DDAH,DDAH-1,DDAHI,HEL-S-16
FUSION GENES

Other Information

Locus ID:

NCBI: 23576
MIM: 604743
HGNC: 2715
Ensembl: ENSG00000153904

Variants:

dbSNP: 23576
ClinVar: 23576
TCGA: ENSG00000153904
COSMIC: DDAH1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000153904ENST00000284031O94760
ENSG00000153904ENST00000284031B1AKK2
ENSG00000153904ENST00000426972O94760
ENSG00000153904ENST00000535924O94760
ENSG00000153904ENST00000633113B4DYP1

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of nitric oxideREACTOMER-HSA-202131
eNOS activation and regulationREACTOMER-HSA-203765
eNOS activationREACTOMER-HSA-203615

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
172731692007Disruption of methylarginine metabolism impairs vascular homeostasis.117
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
227008612012Altered DNA methylation profile in idiopathic pulmonary fibrosis.79
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
214938902011Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine.41
196825812009Role of the PRMT-DDAH-ADMA axis in the regulation of endothelial nitric oxide production.39
157817542005Overexpression of dimethylarginine dimethylaminohydrolase reduces tissue asymmetric dimethylarginine levels and enhances angiogenesis.36
216771992011The role of dimethylarginine dimethylaminohydrolase in idiopathic pulmonary fibrosis.24
203810702010Sex-specific proteome differences in the anterior cingulate cortex of schizophrenia.22
201679242010A novel loss-of-function DDAH1 promoter polymorphism is associated with increased susceptibility to thrombosis stroke and coronary heart disease.21

Citation

Dessen P

DDAH1 (dimethylarginine dimethylaminohydrolase 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-06-01

Online version: http://atlasgeneticsoncology.org/gene/53958/ddah1-(dimethylarginine-dimethylaminohydrolase-1)