RHOV (ras homolog family member V)

2014-06-01  

Identity

HGNC
RHOV
LOCATION
15q15.1
LOCUSID
171177
ALIAS
ARHV,CHP,WRCH2

Other Information

Locus ID:

NCBI: 171177
HGNC: 18313
Ensembl: ENSG00000104140

Variants:

dbSNP: 171177
ClinVar: 171177
TCGA: ENSG00000104140
COSMIC: RHOV

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104140ENST00000220507Q96L33
ENSG00000104140ENST00000220507A0A024R9R2

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
368988472023In vivo CRISPR screens identify RhoV as a pro-metastasis factor of triple-negative breast cancer.5
375969642023Prognostic significance of the rho GTPase RHOV and its role in tumor immune cell infiltration: a comprehensive pan-cancer analysis.0
368988472023In vivo CRISPR screens identify RhoV as a pro-metastasis factor of triple-negative breast cancer.5
375969642023Prognostic significance of the rho GTPase RHOV and its role in tumor immune cell infiltration: a comprehensive pan-cancer analysis.0
343266982021RHOV promotes lung adenocarcinoma cell growth and metastasis through JNK/c-Jun pathway.34
348349202021A CRISPR Activation Screen Identifies an Atypical Rho GTPase That Enhances Zika Viral Entry.8
343266982021RHOV promotes lung adenocarcinoma cell growth and metastasis through JNK/c-Jun pathway.34
348349202021A CRISPR Activation Screen Identifies an Atypical Rho GTPase That Enhances Zika Viral Entry.8
301130352018[Mutations in the Effector Domain of RhoV GTPase Impair Its Binding to Pak1 Protein Kinase].3
301130352018[Mutations in the Effector Domain of RhoV GTPase Impair Its Binding to Pak1 Protein Kinase].3
265553872015Atypical RhoV and RhoU GTPases control development of the neural crest.10
265553872015Atypical RhoV and RhoU GTPases control development of the neural crest.10
243887112013The RHOV gene is overexpressed in human non-small cell lung cancer.20
243887112013The RHOV gene is overexpressed in human non-small cell lung cancer.20
223396302012Pak6 protein kinase is a novel effector of an atypical Rho family GTPase Chp/RhoV.15

Citation

Dessen P

RHOV (ras homolog family member V)

Atlas Genet Cytogenet Oncol Haematol. 2014-06-01

Online version: http://atlasgeneticsoncology.org/gene/53970/img/favicon/apple-touch-icon.png