AHCTF1 (AT-hook containing transcription factor 1)

2014-08-01  

Identity

HGNC
LOCATION
1q44
LOCUSID
ALIAS
ELYS,MST108,MSTP108,TMBS62
FUSION GENES

Other Information

Locus ID:

NCBI: 25909
MIM: 610853
HGNC: 24618
Ensembl: ENSG00000153207

Variants:

dbSNP: 25909
ClinVar: 25909
TCGA: ENSG00000153207
COSMIC: AHCTF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000153207ENST00000326225Q8WYP5
ENSG00000153207ENST00000366508Q8WYP5
ENSG00000153207ENST00000498601H7C4S1
ENSG00000153207ENST00000648844Q8WYP5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
170988632006ELYS is a dual nucleoporin/kinetochore protein required for nuclear pore assembly and proper cell division.108
225556032012The nucleoporin ELYS/Mel28 regulates nuclear envelope subdomain formation in HeLa cells.22
278021612016ELYS regulates the localization of LBR by modulating its phosphorylation state.8
317847292019WNT signaling and AHCTF1 promote oncogenic MYC expression through super-enhancer-mediated gene gating.2
310856252019The nucleoporin ELYS regulates nuclear size by controlling NPC number and nuclear import capacity.1

Citation

Dessen P

AHCTF1 (AT-hook containing transcription factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54112/ahctf1-(at-hook-containing-transcription-factor-1)