BRWD1 (bromodomain and WD repeat domain containing 1)

2014-08-01  

Identity

HGNC
BRWD1
LOCATION
21q22.2
LOCUSID
54014
ALIAS
C21orf107,DCAF19,N143,WDR9,WRD9
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 54014
MIM: 617824
HGNC: 12760
Ensembl: ENSG00000185658

Variants:

dbSNP: 54014
ClinVar: 54014
TCGA: ENSG00000185658
COSMIC: BRWD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000185658ENST00000333229Q9NSI6
ENSG00000185658ENST00000341322Q9NSI6
ENSG00000185658ENST00000342449Q9NSI6
ENSG00000185658ENST00000380800Q9NSI6
ENSG00000185658ENST00000412604H0Y5I9
ENSG00000185658ENST00000424441H7C409
ENSG00000185658ENST00000430093H0Y4R9
ENSG00000185658ENST00000445245H0Y4A7
ENSG00000185658ENST00000445668H0Y500
ENSG00000185658ENST00000446924H7BZR9
ENSG00000185658ENST00000455867H0Y463

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-7 signalingREACTOMER-HSA-1266695
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
200140192010Genome wide association (GWA) predictors of anti-TNFalpha therapeutic responsiveness in pediatric inflammatory bowel disease.41
271000872016Trisomy 21 Alters DNA Methylation in Parent-of-Origin-Dependent and -Independent Manners.9
123593272002Characterisation and expression analysis of the WDR9 gene, located in the Down critical region-2 of the human chromosome 21.7
302501682018BRWD1 orchestrates epigenetic landscape of late B lymphopoiesis.4

Citation

Dessen P

BRWD1 (bromodomain and WD repeat domain containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54159/brwd1